探讨肠内营养剂中添加微生物后应用于腹腔感染患者的治疗效果。

选择2011年7月至2014年7月间收治的130例腹腔感染患者的临床资料，患者均行手术治疗，随机分为两组，其中65例作为对照组给予普通肠内营养治疗，65例作为观察组给予微生物制剂肠内营养治疗。两组患者均在手术前、术后第3天、第7天行自然杀伤细胞（NK细胞）、T细胞亚群的检测，并记录两组患者并发症发生情况。

在手术前及术后第3天，两组患者的CD3、CD4、CD8、CD4/CD8和NK细胞水平差异无统计学意义；术后1周时，在CD3、CD4、CD4/CD8和NK细胞等指标上，观察组患者分别为（63±10）%、（40±10）%、1.81±0.2、（20±5）%，均明显高于对照组患者[(56±9)%、（29±8）%、1.34±0.1、（14±3%）],组间差异均有统计学意义（P<0.05）。观察组患者并发症发生率明显低于对照组，差异具有统计学意义（20% vs 40%，χ²=6.190，P=0.013）。

肠内营养剂中添加微生物后应用于腹腔感染患者，能够改善患者术后的免疫紊乱状态，提高机体免疫力，降低术后并发症发生率，有着重要的临床参考价值。

To investigate the effect of applying microbial enteral nutrition to patients with intra-abdominal infection.

From July 2011 to July 2014, the clinical data of 130 cases of abdominal infection were analyzed. The patients underwent surgical treatment and were divided into two groups randomly. Sixty-five cases were given normal enteral nutrition therapy as control group, and 65 patients were given microbial enteral nutrition therapy as the observation group. The natural killer cells (NK cells) and T cell subsets in both groups were tested before surgery, 3 and 7 days after surgery. The complications of the two groups were recorded.

Before surgery and the third day after surgery, the CD3, CD4, CD8, CD4/CD8 and NK cell levels of the two groups were not significantly different. One week after surgery, indicators as CD3, CD4, CD4/CD8 and NK cells, patients in observation group were (63±10)%, (40±10)%, 1.81±0.2, (20±5)%, higher than patients in control group [(56±9)%、(29±8) %、1.34±0.1、(14±3%) ], the differences between the groups were statistically significant (P<0.05). The incidence of complications rate in the observation group was lower than that in the control group (20% vs 40%, χ²=6.190, P=0.013).

By applying microbial enteral nutrition in patients with intra-abdominal infections, postoperative immune disorders can be improved, and the incidence of postoperative complications can be reduced, indicating its important clinical reference value.