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中华普通外科学文献(电子版) ›› 2018, Vol. 12 ›› Issue (04) : 280 -283. doi: 10.3877/cma.j.issn.1674-0793.2018.04.018

所属专题: 文献

综述

腹部外科围手术期肠黏膜屏障损害与全身炎症反应综合征
冀海斌1, 陈强谱1,()   
  1. 1. 256600 滨州医学院附属医院肝胆外科 临床营养支持中心,山东省临床营养与代谢重点实验室
  • 收稿日期:2018-04-04 出版日期:2018-08-01
  • 通信作者: 陈强谱
  • 基金资助:
    山东省普外科临床重点专科建设基金资助项目(ZDZK2013SJ09)

Perioperative intestinal mucosal barrier damage and systemic inflammatory response syndrome in abdominal surgery

Haibin Ji1, Qiangpu Chen1,()   

  1. 1. Department of Hepatobiliary Surgery, Binzhou Medical University Hospital; Clinical Nutrition Support Center; Clinical Nutrition and Metabolism Key Laboratory of Shandong Province, Binzhou 256600, China
  • Received:2018-04-04 Published:2018-08-01
  • Corresponding author: Qiangpu Chen
  • About author:
    Corresponding author: Chen Qiangpu, Email:
引用本文:

冀海斌, 陈强谱. 腹部外科围手术期肠黏膜屏障损害与全身炎症反应综合征[J]. 中华普通外科学文献(电子版), 2018, 12(04): 280-283.

Haibin Ji, Qiangpu Chen. Perioperative intestinal mucosal barrier damage and systemic inflammatory response syndrome in abdominal surgery[J]. Chinese Archives of General Surgery(Electronic Edition), 2018, 12(04): 280-283.

全身炎症反应综合征(SIRS)是腹部外科围手术期常见的问题之一,也是外科医师亟需解决的难题。肠黏膜屏障损害导致肠腔内细菌、细菌产物移位,引起机体免疫细胞激活,促炎介质过度释放,促炎-抗炎细胞因子之间的平衡被打破,在SIRS发生、发展中起到极其重要的推动作用。SIRS增加围手术期并发症的发生率,严重者可引起多器官功能障碍综合征(MODS),甚至多器官功能衰竭(MOF)。研究肠黏膜屏障损害在腹部外科围手术期引起SIRS中的重要作用,可以加快患者术后恢复进程。

Systemic inflammatory response syndrome (SIRS) is one of the common and urgent problems during perioperative period of abdominal surgery. Intestinal mucosal barrier damage leads to the shift of bacteria and bacterial terms, activation of immune cells in the body, excessive release of pro-inflammatory mediators, breaking of the balance between pro-inflammatory and anti-inflammatory cytokines, and plays an important role in promoting the development and progression of SIRS. SIRS increases the incidence of perioperative complications, which will cause multiple organ dysfunction syndrome (MODS) or even multiple organ failure (MOF) in severe cases. To promote the postoperative recovery of patients, it is necassary to study the important role of intestinal mucosal barrier damage in SIRS during perioperative period of abdominal surgery.

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