切换至 "中华医学电子期刊资源库"

中华普通外科学文献(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 137 -142. doi: 10.3877/cma.j.issn.1674-0793.2019.02.011

所属专题: 文献

论著

食管胃结合部腺癌炎性反应和营养状态变化及对预后的影响
曹能琦1, 曹晓刚1,(), 孙宝林2, 全勇辉2, 魏春生1   
  1. 1. 211200 南京,东南大学附属中大医院溧水分院普外科
    2. 211200 南京,东南大学附属中大医院胸外科
  • 收稿日期:2018-07-17 出版日期:2019-04-01
  • 通信作者: 曹晓刚

Changes of inflammation and nutritional status after operation in adenocarcinoma of the esophago-gastric junction and its effect on prognosis

Nengqi Cao1, Xiaogang Cao1,(), Baolin Sun2, Yonghui Quan2, Chunsheng Wei1   

  1. 1. Department of General Surgery, Jiangsu 211200, China
    2. Department of Thoracic Surgery, Lishui Branch, Zhongda Hospital Affiliated to Southeast University, Jiangsu 211200, China
  • Received:2018-07-17 Published:2019-04-01
  • Corresponding author: Xiaogang Cao
  • About author:
    Corresponding author: Cao Xiaogang, Email:
引用本文:

曹能琦, 曹晓刚, 孙宝林, 全勇辉, 魏春生. 食管胃结合部腺癌炎性反应和营养状态变化及对预后的影响[J/OL]. 中华普通外科学文献(电子版), 2019, 13(02): 137-142.

Nengqi Cao, Xiaogang Cao, Baolin Sun, Yonghui Quan, Chunsheng Wei. Changes of inflammation and nutritional status after operation in adenocarcinoma of the esophago-gastric junction and its effect on prognosis[J/OL]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(02): 137-142.

目的

探讨炎性指标中性粒细胞-淋巴细胞比(NLR)、血小板-淋巴细胞比(PLR)和营养状态指标预后营养因子(PNI)、体质量指数(BMI)、血红蛋白、白蛋白、前白蛋白对于食管胃结合部腺癌(AEG)患者预后的影响。

方法

回顾性分析2010年4月至2013年4月东南大学附属中大医院溧水分院150例Ⅱ/Ⅲ型AEG手术患者的临床资料,术前1周内获得NLR、PLR、BMI、血红蛋白、白蛋白、前白蛋白和PNI数据并分组,采用受试者工作特征曲线(ROC)分析各个检测指标的敏感度、特异度、准确性、最佳截断值以及曲线下面积(AUC),评估其诊断价值;Kaplan-Meier曲线和Log-rank检验计算生存率;COX模型来分析患者预后的影响因素。

结果

NLR、PLR和PNI的最佳截断值分别是3.5(AUC为0.591,敏感度为26.8,特异度为89.4)、171(AUC为0.531,敏感度为23.6,特异度为81.3)和51.3(AUC为0.599,敏感度为63.1,特异度为57.2)。5年平均生存时间46.3个月,Kaplan-Meier生存曲线显示,前白蛋白<180 mg/L(P<0.001)、NLR>3.5(P<0.001)和BMI<18.5 kg/m2P<0.001)的AEG患者预后生存时间较短(均P=0.010)。多因素回归分析显示,TNM分期(P<0.001,95%CI=1.739~3.525)、BMI(P=0.011,95%CI=0.564~0.928)、NLR(P<0.001,95%CI=1.617~3.280)和前白蛋白水平(P<0.001,95%CI=0.310~0.592)是影响AEG患者预后的独立危险因素。NLR与患者的肿瘤分型、肿瘤大小有关(χ2=7.156、7.567,P= 0.028、0.023);BMI与患者年龄、手术时间有关(χ2=7.339、6.414,P=0.025、0.011);前白蛋白与患者性别、肿瘤大小、分化程度和TNM分期有关(χ2=4.746、13.574、3.888、4.024,P=0.029、<0.001、0.049、0.045)。

结论

炎性反应和营养状态会促进Ⅱ/Ⅲ型AEG手术患者的疾病进展,BMI、NLR和前白蛋白水平是影响AEG患者预后的独立危险因素。

Objective

To investigate the value of inflammatory markers (NLR and PLR) and nutritional indicators including prognostic nutritional factors (PNI), body mass index (BMI), hemoglobin, albumin, and prealbumin in patients with adenocarcinoma of the esophagogastric junction (AEG).

Methods

Between April 2010 and April 2013, a total of one hundred and fifty surgical AEG patients of type Ⅱ/Ⅲ. Data of NLR, PLR, BMI, hemoglobin, albumin, prealbumin and PNI were obtained within 1 week before operation. The sensitivity, specificity, accuracy, best cut-off value and area under the curve (AUC) of each index were analyzed by the receiver operating characteristic curve (ROC) to evaluate their diagnostic value. Kaplan-Meier curve and Log-rank test were used to calculate the survival rate. COX model was used to analyze the prognostic factors.

Results

The cut-off values of NLR, PLR and PNI were 3.5 (AUC 0.591, sensitivity 26.8, specificity 89.4), 171 (AUC 0.531, sensitivity 23.6, specificity 81.3) and 51.3 (AUC 0.599, sensitivity 63.1, specificity 57.2), respectively. The average survival time was 46.3 months in 5 years. Kaplan-Meier survival curve showed that the prognostic survival time of AEG patients with prealbumin<180 mg/L, NLR>3.5 and low BMI (<18.5 kg/m2) was shorter (all P=0.010). Multivariate regression analysis showed that TNM stage (P<0.001, 95%CI=1.739-3.525), BMI (P=0.011, 95%CI=0.564-0.928), NLR (P<0.001, 95%CI=1.617-3.280) and prealbumin (P<0.001, 95%CI=0.310-0.592) were independent risk factors for the prognosis of AEG patients. NLR was correlated with tumor type and tumor size (χ2=7.156, 7.567; P=0.028, 0.023); BMI was correlated with age and operation time (χ2=7.339, 6.414; P=0.025, 0.011); prealbumin was correlated with gender, tumor size, differentiation and TNM stage (χ2=4.746, 13.574, 3.888, 4.024; P=0.029, <0.001, 0.049, 0.045).

Conclusions

Inflammatory response and nutritional status promote disease progression in AEG patients with type /. BMI, NLR and prealbumin levels are independent risk factors for the prognosis of AEG patients.

表1 NLR、PLR和PNI的诊断价值评价
表2 150例食管胃结合部腺癌患者术后5年存活的单因素分析
图2 不同炎性反应和营养状态的食管胃结合部患者生存曲线比较 A为NLR,B为BMI,C为前白蛋白
表3 影响150例食管胃结合部腺癌患者预后的多因素分析
表4 NLR、BMI和前白蛋白与患者的临床病理特点联系
图1 NLR、PLR和PNI各指标的ROC曲线
[1]
Fitzmaurice C,Dicker D,Pain A, et al. The global burden of cancer 2013[J]. JAMA Oncol, 2015, 1(4): 505-527.
[2]
Siewert JR. Adenocarcinoma of the esophago-gastric junction[J]. Gastric Cancer, 1999, 2(2): 87-88.
[3]
Mullen JT,Kwak EL, Hong TS: What's the best way to treat GE junction tumors? Approach like gastric cancer[J]. Ann Surg Oncol, 2015, 23(12): 3780-3785.
[4]
Matsuda T,Kurokawa Y,Yoshikawa T, et al. Clinicopathological characteristics and prognostic factors of patients with Siewert type II esophagogastric junction carcinoma: A retrospective multicenter study[J]. World J Surg, 2016, 40(7): 1672-1679.
[5]
Zheng Z,Cai J,Yin J, et al. Transthoracic versus abdominal-transhiatal resection for treating Siewert type/adenocarcinoma of the esophagogastric junction: a meta-analysis[J]. Int J Clin Exp Med, 2015, 8(10): 17167-17182.
[6]
Crumley AB,McMillan DC,McKernan M, et al. An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer[J]. Br J Cancer, 2006, 94(11): 1568-1571.
[7]
Nozoe T,Ninomiya M,Maeda T, et al. Prognostic nutritional index: a tool to predict the biological aggressiveness of gastric carcinoma[J]. Surg Today, 2010, 40: 440-443.
[8]
Hasegawa S,Yoshikawa T,Rino Y, et al. Priority of lymph node dissection for Siewert type/ adenocarcinoma of the esophagogastric junction[J]. Ann Surg Oncol, 2013, 20(13): 4252-4259.
[9]
Balkwill F,Mantovani A. Inflammation and cancer: back to Virchow? [J]. Lancet, 2001, 357: 539-545.
[10]
方东,王志红. 中性粒细胞与淋巴细胞比值和消化系统恶性肿瘤患者预后关系的研究进展[J]. 国际消化病杂志, 2014, 34(6): 393-395.
[11]
Yuan D,Zhu K,Li K, et al. The preoperative neutrophil-lymphocyte ratio predicts recurrence and survival among patients undergoing R0 resections of adenocarcinomas of the esophagogastric junction[J]. J Surg Oncol, 2014, 110(3): 333-340.
[12]
Urabe M,Yamashita H,Watanabe T, et al. Comparison of prognostic abilities among preoperative laboratory data indices in patients with resectable gastric and esophagogastric junction adenocarcinoma[J]. World J Surg, 2018, 42(1): 185-194.
[13]
Wightman SC,Posner MC,Patti MG, et al. Extremes of body mass index and postoperative complications after esophagectomy[J]. Dis Esophagus, 2017, 30(5): 1-6.
[14]
Bickenbach KA,Denton B,Gonen M, et al. Impact of obesity on perioperative complications and long-term survival of patients with gastric cancer[J]. Ann Surg Oncol, 2013, 20(3): 780-787.
[15]
Han WX,Chen ZM,Wei ZJ, et al. Preoperative pre-albumin predicts prognosis of patients after gastrectomy for adenocarcinoma of esophagogastric junction[J]. World J Surg Oncol, 2016, 14(1): 279.
[16]
Suh B,Park S,Shin DW, et al. Low albumin-to-globulin ratio associated with cancer incidence and mortality in generally healthy adults[J]. Ann Oncol, 2014, 25(11): 2260-2266.
[17]
张理想,韩文秀,徐阿曼, 等. 免疫和营养相关指数与胃癌患者预后的关系[J]. 中华普通外科学杂志, 2018, 33(1): 16-19.
[18]
Zhang L,Su Y,Chen Z, et al. The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type / adenocarcinoma of esophagogastric junction[J]. Medicine (Baltimore), 2017, 96(30): e7647.
[1] 汪洪斌, 张红霞, 何文, 杜丽娟, 程令刚, 张雨康, 张萌. 低级别阑尾黏液性肿瘤与阑尾黏液腺癌超声及超声造影特征分析[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 865-871.
[2] 李子禹, 卢信星, 李双喜, 陕飞. 食管胃结合部腺癌腹腔镜手术重建方式的选择[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 5-8.
[3] 李乐平, 张荣华, 商亮. 腹腔镜食管胃结合部腺癌根治淋巴结清扫策略[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 9-12.
[4] 许杰, 李亚俊, 韩军伟. 两种入路下腹腔镜根治性全胃切除术治疗超重胃癌的效果比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 19-22.
[5] 高杰红, 黎平平, 齐婧, 代引海. ETFA和CD34在乳腺癌中的表达及与临床病理参数和预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 64-67.
[6] 张洁, 罗小霞, 余鸿. 系统性免疫炎症指数对急性胰腺炎患者并发器官功能损伤的预测价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 68-71.
[7] 李代勤, 刘佩杰. 动态增强磁共振评估中晚期低位直肠癌同步放化疗后疗效及预后的价值[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 100-103.
[8] 燕速, 霍博文. 腹腔镜食管胃结合部腺癌根治性切除术[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 13-13.
[9] 王湛, 李文坤, 杨奕, 徐芳, 周敏思, 苏珈仪, 王亚丹, 吴静. 炎症指标在早发性结直肠肿瘤中的应用[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 802-810.
[10] 刘琦, 王守凯, 王帅, 苏雨晴, 马壮, 陈海军, 司丕蕾. 乳腺癌肿瘤内微生物组的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 841-845.
[11] 王景明, 王磊, 许小多, 邢文强, 张兆岩, 黄伟敏. 腰椎椎旁肌的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 846-852.
[12] 王誉英, 刘世伟, 王睿, 曾娅玲, 涂禧慧, 张蒲蓉. 老年乳腺癌新辅助治疗病理完全缓解的预测因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 641-646.
[13] 王帅, 张志远, 苏雨晴, 李雯雯, 王守凯, 刘琦, 李文涛. 孟德尔随机化及其在乳腺癌研究中的应用进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 671-676.
[14] 崔军威, 蔡华丽, 胡艺冰, 胡慧. 亚甲蓝联合金属定位夹及定位钩针标记在乳腺癌辅助化疗后评估腋窝转移淋巴结的临床应用价值探究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 625-632.
[15] 杨菲, 刘腾飞, 赵志军, 李睿聪, 张颉, 刘妍, 赵珍. 血清维生素水平与分化型甲状腺癌的关联性研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 633-640.
阅读次数
全文


摘要