探讨肠型脂肪酸结合蛋白（I-FABP）在重症急性胰腺炎（SAP）患者胃肠道功能障碍严重程度以及病情评估中的意义。

选取2016年12月至2018年12月青岛市第八人民医院收治的34例SAP患者，收集入院时患者血清I-FABP、降钙素原（PCT）、C反应蛋白（CRP）浓度以及白细胞计数等临床资料，并进行胃肠功能障碍程度评分以及急性生理与慢性健康状况（APACHEⅡ）评分，将以上指标与I-FABP质量浓度进行相关性分析。

入院时I-FABP浓度为（551±204）ng/L，PCT浓度为（3.36±1.79）μg/L，CRP浓度为（171±73）mg/L，白细胞计数为（14.47±4.09）×10⁹/L，APACHE Ⅱ评分为（12±5）分，胃肠道功能障碍评分为（10±2）分。患者血清I-FABP浓度和入院时PCT、CRP浓度、白细胞计数、APACHEⅡ评分、胃肠道功能评分均呈正相关关系（P<0.01），r分别为0.537、0.662、0.730、0.716、0.686。

血清I-FABP与血清炎性指标、APACHEⅡ评分和胃肠道功能评分存在相关性，有助于评估SAP患者的胃肠功能障碍及疾病严重程度。

To study the significance of intestinal fatty acid binding protein (I-FABP) in the severity of gastrointestinal dysfunction and the assessment of disease severity in severe acute pancreatitis (SAP) patients.

From December 2016 to December 2018, thirty-four patients with SAP admitted to Qingdao Eighth People’s Hospital were selected. Levels of serum I-FABP, procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count were collected at admission. The patients were scored for gastrointestinal dysfunction and Acute Physiological and Chronic Health Status Score Ⅱ (APACHEⅡ). The correlations between serum I-FABP level and the above markers were analyzed.

The concentration of I-FABP at admission was (551±204) ng/L, the PCT concentration was (3.36±1.79) μg/L, the CRP concentration was (171±73) mg/L, and the white blood cell count was (14.47±4.09)×10⁹/L, APACHE score was (12±5), and gastrointestinal function score was (10±2). There was positive correlation among the serum I-FABP concentration and the concentration of PCT, CRP, white blood cell count, APACHEⅡ score, and gastrointestinal function score (P<0.01), and r was 0.537, 0.662, 0.730, 0.716, and 0.686 respectively.

Serum I-FABP is correlated with serum inflammatory markers, APACHE Ⅱ and gastrointestinal function score, which is helpful to evaluating gastrointestinal dysfunction and severity of SAP.