To investigate the influences of controlled low central venous pressure(CLCVP) on the cardiopulmonary and hepatorenal functions of patients undergoing right hemihepatectomy.

Sixty patients with hepatocellular carcinoma were randomly divided into 4 groups. Group A were those without hepatic portal occlusion (A1 not given CLCVP, A2 given CLCVP) and group B were patients under hepatic portal occlusion (B1 not given CLCVP, B2 given CLCVP). The volume of fluid infusion, RBC, blood loss and urine were recorded. The arterial blood was drawn before anesthesia(T0), pre-hepatectomy(T1), post- hepatectomy(T2), 24 hours after operation(T3) in group A, and before anesthesia(T0), pre-occlusion(T1), post-occlusion(T2), 24 hours after operation(T3)in group B. Blood-gas analysis, cardiac enzymes and hepatorenal function were tested.

The volume of fluid infusion, RBC, blood loss and urine of patients with CLCVP were statistically lower than those of patients without CLCVP(P<0.05). There were no statistical differences of A-aDO₂, RI, BUN, Cr and TnT among the four groups on T0,T1,T2,T3. CK-MB on T3 was statistically increased and the variations in group B1 were lower than those in the other three groups(P=0.037). AST and ALT were statistically increased on T3 in four groups, and the elevations in group A1 was lower than those in the other three groups(P=0.002, P=0.018, respectively).

CLCVP can effectively decrease the volume of fluid infusion during the operation, RBC and blood loss in patients undergoing right hemihepatectomy, and has no influences on cardiopulmonary and renal functions. More attention should be paid to increased liver enzymes of the patients.