Effect of liver fibrosis with modified splenopneumopexy

doi:10.3877/cma.j.issn.1647-0793.2013.02.009

Abstract

Abstract:

Objective

To evaluate the changes of the serum markers for hepatic fibrogenesis in patients of portal hypertension after modified splenopneumopexy treatment.

Methods

From June 2008 to December 2012, 32 patients with portal hypertension were given modified splenopneumopexy in the First Affiliated Hospital of Zhengzhou University. The levels of COL-Ⅲ, COL-Ⅳ, MMP-1, and TIMP-1were recorded separately before and 6 months after the operation for a statistical comparison.

Results

After 6 months, the levels of COL-Ⅲ decreased from (20.25±3.20) μg/L to (16.32±2.35) μg/L, COL-Ⅳ decreased from (112.21±23.90) μg/L to (57.32±18.74) μg/L, the levels of MMP-1 increased from (16.68±8.56) μg/L to (26.85±8.95) μg/L, TIMP-1 decreased from (227.56±76.84) μg/L to (132.35±62.42) μg/L. There were significantly statistical differences between any two groups, P<0.01.

Conclusion

The modified splenopneumopexy helps to slow down the degree of liver fibrosis.

Key words: Portal hypertension, Modified splenopneumopexy, Liver fibrosis

Xiao-wei DANG, Zhi-qiang YANG, Shi-shi QIAO, Da-qian XU, Peng LI, Zhao-yang WANG, Zhen-tao YAO, Pei-qin XU. Effect of liver fibrosis with modified splenopneumopexy[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(02): 118-120.

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Figures/Tables 1

References 9

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?	例数	COL-Ⅲ	COL-Ⅳ	MMP-1	TIMP-1
术前	32	20.25±3.20	112.21±23.90	16.68±8.56	227.56±76.84
术后6月	28	16.32±2.35	57.32±18.74	26.85±8.95	132.35±62.42
t值	?	5.355	9.797	4.495	5.219
P值	?	< 0.01	< 0.01	< 0.01	< 0.01

?	例数	COL-Ⅲ	COL-Ⅳ	MMP-1	TIMP-1
术前	32	20.25±3.20	112.21±23.90	16.68±8.56	227.56±76.84
术后6月	28	16.32±2.35	57.32±18.74	26.85±8.95	132.35±62.42
t值	?	5.355	9.797	4.495	5.219
P值	?	< 0.01	< 0.01	< 0.01	< 0.01

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