Peroxisome proliferator-activated receptorγinhibits migration of hepatocellular carcinoma cells

doi:10.3877/cma.j.issn.1674-0793.2007.02.006

Abstract

Abstract:

Objective

To investigate the effect of peroxisome proliferators-activated receptorγ(PPARγ)on migration of hepatocellular carcinoma cells and its underlying mechanisms.

Methods

Migration of HCC cell line BEL-7402 with the treatment of troglitazone and rosiglitazone was measured by a wound healing assay.PPARγmRNA and protein were assessed by RT-PCR,immunofluorescence chemistry,and Western Blotting analysis,respectively.

Results

Troglitazone and rosiglitazone inhibited the migration of BEL-7402 cells,both medcines activated PPARγsignaling pathway on ligand-dependent effect.

Conclusion

PPARγactivation inhibited the migration of HCC.

Key words: PPARγ, Troglitazone, Rosiglitazone, Hepatocellular carcinoma, Migration

Liang-qi CAO, Qian Wang, Xi-lin CHEN, Mao-chuan ZHEN, Xiao-hui HUANG, Xin-hui FU. Peroxisome proliferator-activated receptorγinhibits migration of hepatocellular carcinoma cells[J]. Chinese Archives of General Surgery(Electronic Edition), 2007, 01(02): 85-88.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2007.02.006

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2007/V01/I02/85

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