Abstract:

Objective

To evaluate the influence of various clinicopathologic factors on the prognoses of patients with hilar cholangiocarcinoma(HCC).

Methods

Retrospectively analyzed the clinical data of 67 HCCs in our hospital.

Results

The overall survival was significant difference in the group with different operative modus(P<0.001).The 1,3-year survival rate was significantly improved in resection group comparing with that in non-resection group,and the overall surviva1 was significantly improved in the radical resection group comparing with that in the palliative resection group.Preoperative evaluation of T staging and Bismuth-Corlette typing could guide the resectability opportunity and modus operandi selection.The likelihood of resection and achieving tumor-free margin decreased progressively with increasing T stage(P<0.001);the patient of T3 had little resectability opportunity.The results of univariate analysis showed that the major significant prognostic factors for influencing survival of these patients were surgical management,the TNM staging,lymph node metastasis,portal vein invasion,size of tumor,T staging,local infiltration and metastasis(P<0.05).Surgical management and the TNM staging were the two most important prognostic factors determined by multivariate analysis using the Cox Proportional Hazards Model.

Conclusions

Radical resection is the most important prognostic factor of HCC.Invasive resection could improve radical operation.Preoperative evaluation of T staging and Bismuth-Corlette typing could help increasing the possibility of resection and radical operation.

Key words: Bile duct neoplasms, Surgical procedure, prognosis