Mechanism of multiple organ dysfunction syndrome results from hemorrhagic hypovolemic shock

doi:10.3877/cma.j.issn.1674-0793.2008.01.011

Abstract

Abstract:

Objective

To investigate the relationship between serum levels of TNF-α and IL-1 and prognosis of hemorrhagic hypovolemic shock.

Methods

The serum levels of TNF-α and IL-1 were measured by ELISA in 29 hemorrhagic hypovolemic shock patients,20 patients for selective surgery served as a control group.The relationship between serum levels of TNF-α, IL-1 and MODS were analyzed.

Results

The morbidity rates of SIRS, MODS and infection in hemorrhagic hypovolemic shock group were significantly higher than those in control group (P＜0.05).The serum levels of TNF-α and IL-1 in hemorrhagic hypovolemic shock group were significantly higher than those in control group(P＜0.05).The serum levels of TNF-α in MODS group were significantly higher than that in non-MODS group(P＜0.05).In hemorrhagic hypovolemic shock group, the serum levels of TNF-α in the dieds were higher than those in survival patients(P＜0.05).

Conclusion

SIRS is a main cause of MODS and often occurred after hemorrhagic hypovolemic shock.The concentration of TNF-α in serum may be related closely with prognosis after hemorrhagic hypovolemic shock.

Key words: Shock, hemorrhagic, Multiple organ dysfunction syndrome, Systemic inflammation response syndrome, Tumor necrosis factor-α, Interleukin-1

Ze-yu WU, Jin WAN, Xiang-dong GUAN, Jia-lin DU. Mechanism of multiple organ dysfunction syndrome results from hemorrhagic hypovolemic shock[J]. Chinese Archives of General Surgery(Electronic Edition), 2008, 02(01): 32-34.

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