The expression of platelet-derived endothelial cell growth factor and microvascular density in human gastric carcinoma

doi:10.3877/cma.j.issn.1674-0793.2008.04.005

Abstract

Abstract:

Objective

To explore the relationship between the expression of platelet-derived endothelial cell growth factor(PD-ECGF) together with microvascular density (MVD) and biological behaviour and tumor angiogenesis in gastric carcinoma.

Methods

Elivision^TM immunohistochemical method was performed to detect the expression of PD-ECGF and CD34，evaluated the value of MVD in fifty-two gastric carcinoma specimens.Clinicopathologic materials of patients were assayed retrospectively.

Results

The positive expression of PD-ECGF was 59.62%, and the value of MVD was 72.60±16.87.The rates of expression and the value of MVD in the group with lymph node metastasis and the group with or exceed serosa invasion were higher than that without lymph node metastasis and without serosa invasion respectively. MVD in group of Ⅲ+Ⅳstage was significantly higher than that inⅠ+Ⅱstage.MVD in the PD-ECGF positive-expression group was significantly higher than that in negative-expression group.

Conclusion

PD-ECGF participates in the invasion and metastasis,angiogenesis of human gastric carcinoma.PD-ECGF can be selected asa target for tumor anti-angiogenesis treatment.

Key words: Gastric carcinoma, PD-ECGF, Microvascular Density, Angiogenesis

Dun-jun GE, Xi-hong HU, Li-ming HU. The expression of platelet-derived endothelial cell growth factor and microvascular density in human gastric carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2008, 02(04): 271-274.

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Figures/Tables 1

References 12

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	例数	PD-ECGF			MVD
	例数	阴性	阳性	P值	计数	P值
性别
女性	10	3	7	0.699	72.13±9.44	0.909
男性	42	18	24		72.83±18.28
年龄（岁）
＜60	26	10	16	0.777	71.46±17.76	0.604
≥60	26	11	15		73.92±16.18
部位
胃底贲门	12	5	7	0.986	71.83±18.23	0.959
胃体	18	7	11		73.59±16.00
胃窦	22	9	13		72.42±17.57
大小（cm）
＜5	26	12	14	0.397	69.04±18.25	0.119
≥5	26	9	17		76.35±14.82
淋巴结转移
无	15	11	4	0.002^*	56.69±11.56	＜0.01^*
有	37	10	27		79.18±14.18
TNM
Ⅰ+Ⅱ	27	14	13	0.08	66.38±17.12	0.004^*
Ⅲ+Ⅳ	25	7	18		79.51±13.92
细胞分化
高、中分化	24	15	9	0.004^*	71.55±14.80	0.208
低、未分化	28	6	22		74.38±19.79

	例数	PD-ECGF			MVD
	例数	阴性	阳性	P值	计数	P值
性别
女性	10	3	7	0.699	72.13±9.44	0.909
男性	42	18	24		72.83±18.28
年龄（岁）
＜60	26	10	16	0.777	71.46±17.76	0.604
≥60	26	11	15		73.92±16.18
部位
胃底贲门	12	5	7	0.986	71.83±18.23	0.959
胃体	18	7	11		73.59±16.00
胃窦	22	9	13		72.42±17.57
大小（cm）
＜5	26	12	14	0.397	69.04±18.25	0.119
≥5	26	9	17		76.35±14.82
淋巴结转移
无	15	11	4	0.002^*	56.69±11.56	＜0.01^*
有	37	10	27		79.18±14.18
TNM
Ⅰ+Ⅱ	27	14	13	0.08	66.38±17.12	0.004^*
Ⅲ+Ⅳ	25	7	18		79.51±13.92
细胞分化
高、中分化	24	15	9	0.004^*	71.55±14.80	0.208
低、未分化	28	6	22		74.38±19.79

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