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Chinese Archives of General Surgery(Electronic Edition) ›› 2009, Vol. 03 ›› Issue (05): 54-57. doi: 10.3877/cma.j.issn.1674-0793.2009.05.020

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Qi-wen YANG1, Hui WANG1,(), Ying-chun XU1, Bin CAO1, Xian LI1, Zhi-dong HU1, Hong FAN1, Kong LIAO1, Yun-zhuo CHU1, Ji ZENG1, Zhen-ying LIU1, Rong ZHANG1, Xiu-li XU1, Yong WANG1, Chao ZHUO1, Dan-hong SU1, Chun-mei ZHOU1, Hong-li, SUN1, Xiu-li XIE1, Min-jun CHEN1   

  1. 1.Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2009-07-08 Online:2009-10-01 Published:2024-12-01
  • Contact: Hui WANG

Abstract:

Objective

To investigate the distribution and in vitro susceptibility of intra-abdominal causing pathogens from 14 teaching hospitals of different regions between Oct. 2006 and Oct. 2007.

Methods

Isolates were collected from 14 hospitals and reidentificated in central labortory. MIC of 29 antimicrobial agents were determined by agar dilution method.Data were analyzed by WHONET5.4 software.

Results

Seven hundred and forty-two intra-abdominal infection cases were collected and 743 isolates were acquired. Among them,76.7%(570/743)were gram-negative and 23.3%(73/743)were gram-positive.The top five species included Escherichia coli(38.8%),Klebsiella pneumoniae(10.2%),Pseudomonas aeruginosa(9.2%),Enterococcus faecium(8.2%)and Staphylococcus aureus (4.4%).Against Enterobacteriaceae,antimicrobial agents with more than 90%susceptibility included meropenem, imipenem, tigecycline, amikacin and piperacillin-tazobactam. Against ESBLs-producing E.coli and K.pneumoniae isolates,antimicrobial agents with more than 90%susceptibility included meropenem(100%), imipenem (100%), tigecycline(100%)and piperacillin-tazobactam (91.5%-91.7%). The percentage of multidrug-resistant isolates in P.aeruginosa was 14.71%,while as this value was 61.29%in A.baumannii.The percentage of MRSA in Staphylococcus aureus was 69.7%and all isolates were susceptible to tigecycline,vancomycin and teicoplanin.All E.faecalis and E.faecium isolates were susceptible to tigecycline.Antimictobial agents with high susceptibility included vancomycin(100%),teicoplanin(100%),ampicillin(81.5%)against E.faecalis and vancomycin,teicoplanin(96.7%)against E.faecium.

Conclusions

Themain intra-abdominalcausing pathogens are gram-negative bacilli, especially enterobacteriaceae. Tigecycline, carbapenem, piperacillintazobactam and amikacin remain relatively high activity against Enterobacteriaceae. The resistance situation of non-fermenting pathogens is a worrying problem.Tigecycline,vancomycin and teicoplanin remain high activity againstgram-positive cocci.

Key words: Abdominal cavity; Microbiology; Enterobacteriaceae; Pseudomonas aeruginosa; Acinetobacter;Staphylococci;Enterococci

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