Abstract:
Objective
To investigate the distribution and in vitro susceptibility of intra-abdominal causing pathogens from 14 teaching hospitals of different regions between Oct. 2006 and Oct. 2007.
Methods
Isolates were collected from 14 hospitals and reidentificated in central labortory. MIC of 29 antimicrobial agents were determined by agar dilution method.Data were analyzed by WHONET5.4 software.
Results
Seven hundred and forty-two intra-abdominal infection cases were collected and 743 isolates were acquired. Among them,76.7%(570/743)were gram-negative and 23.3%(73/743)were gram-positive.The top five species included Escherichia coli(38.8%),Klebsiella pneumoniae(10.2%),Pseudomonas aeruginosa(9.2%),Enterococcus faecium(8.2%)and Staphylococcus aureus (4.4%).Against Enterobacteriaceae,antimicrobial agents with more than 90%susceptibility included meropenem, imipenem, tigecycline, amikacin and piperacillin-tazobactam. Against ESBLs-producing E.coli and K.pneumoniae isolates,antimicrobial agents with more than 90%susceptibility included meropenem(100%), imipenem (100%), tigecycline(100%)and piperacillin-tazobactam (91.5%-91.7%). The percentage of multidrug-resistant isolates in P.aeruginosa was 14.71%,while as this value was 61.29%in A.baumannii.The percentage of MRSA in Staphylococcus aureus was 69.7%and all isolates were susceptible to tigecycline,vancomycin and teicoplanin.All E.faecalis and E.faecium isolates were susceptible to tigecycline.Antimictobial agents with high susceptibility included vancomycin(100%),teicoplanin(100%),ampicillin(81.5%)against E.faecalis and vancomycin,teicoplanin(96.7%)against E.faecium.
Conclusions
Themain intra-abdominalcausing pathogens are gram-negative bacilli, especially enterobacteriaceae. Tigecycline, carbapenem, piperacillintazobactam and amikacin remain relatively high activity against Enterobacteriaceae. The resistance situation of non-fermenting pathogens is a worrying problem.Tigecycline,vancomycin and teicoplanin remain high activity againstgram-positive cocci.
Key words:
Abdominal cavity; Microbiology; Enterobacteriaceae; Pseudomonas aeruginosa; Acinetobacter;Staphylococci；Enterococci
Qi-wen YANG, Hui WANG, Ying-chun XU, Bin CAO, Xian LI, Zhi-dong HU, Hong FAN, Kong LIAO, Yun-zhuo CHU, Ji ZENG, Zhen-ying LIU, Rong ZHANG, Xiu-li XU, Yong WANG, Chao ZHUO, Dan-hong SU, Chun-mei ZHOU, Hong-li, SUN, Xiu-li XIE, Min-jun CHEN. [J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(05): 54-57.