Expression and implication of CD15s and CD138 in hepatocellular carcinoma

doi:10.3877/cma.j.issn.1674-0793.2010.04.006

Abstract

Abstract:

Objective

To investigate the relationship of CD15s and CD138 in invasion and metastasis of hepatocellular carcinoma(HCC).

Methods

Immunohistochemical method was used to detect CD15s and CD138 expression in 110 cases of HCC from February 1990 to May 2006.

Results

Positive expression rate of CD15s and CD138 in HCC were 39.1% and 46.4%, respectively.HCC with positive expression of CD15s had higher metastatic rate(P<0.05), poorer 5-years survival rate(P<0.05); HCC with positive CD138 expression had lower metastatic rate(P<0.05) and higher 5-years survival rate(P<0.05). The expression of CD15s was negatively correlated to CD138 expression in HCC(P<0.05).

Conclusions

The expression of CD15s and CD138 is closely related to the potential of metastasis and survival rate in HCC.CD15s and CD138 may be clinically used as prognostic indicators in HCC.

Key words: Hepatocellular carcinoma, CD15s, CD138, Neoplasm metastasis

Pei-zhong SHANG, Yong-qing LI, Jian-jun MIAO, Ying-li XIAO, Run-ling NAN, Hua-ping GU. Expression and implication of CD15s and CD138 in hepatocellular carcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2010, 04(04): 315-318.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2010.04.006

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2010/V04/I04/315

Figures/Tables 3

References 16

1	袁建寰，林静吟，夏婷，等. CD15s与P-选择素在宫颈鳞状细胞癌的表达和意义.武汉大学学报（医学版），2006，27(1):44-46.
2	李小卫，刘平，丁彦青. Sialyl Lewis-X抗原在大肠癌肝转移中的作用研究及临床意义.临床肿瘤学杂志，2006，11(4):269-273.
3	翟瑾洁，李太原. SLeX抗原在肿瘤转移中的作用及与选择素、NK细胞的关系.实用临床医学，2007，8(6):133-135.
4	尚培中，张金江，贾国洪，等.基质金属蛋白酶-2和唾液酸化Lewis X在乳腺癌中的表达及其意义[J/CD].中华乳腺病杂志:电子版，2008，2(2):177-183.
5	尚培中，朱习琴，苗建军，等. MMP-9和CD15s与胃癌血管生成的相关性研究及其临床意义.河北北方学院学报（医学版），2008，25(1):12-13.
6	尚培中，王兵，万立，等. SLeX和p16在甲状腺乳头状癌中的表达及其意义.中华内分泌外科杂志，2009，3(3):151-153.
7	Mizuguchi S, Nishiyama N, Iwata T，et al. Serum Sialyl Lewis x and cytokeratin 19 fragment as predictive factors for recurrence in patients with stage Ⅰ non-small cell lung cancer. Lung Cancer，2007，58(3):369-375.
8	McDonald B, Spicer J, Giannias B，et al. Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int J Cancer，2009，125(6):1298-1305.
9	Zellweger T, Ninck C, Bloch M，et al. Expression patterns of potential therapeutic targets in prostate cancer.Int J Cancer，2005，113(4):619-628.
10	Andersen NF, Standal T, Nielsen JL，et al.Syndecan-1 and angiogenic cytokines in multiple myeloma：correlation with bone marrow angiogenesis and survival. Br J Haematol，2005，128(2):210-217.
11	Chen CL, Ou DL. Expression of syndecan-1 (CD138) in nasopharyngeal carcinoma is correlated with advanced stage and poor prognosis. Hum Pathol，2006，37(10):1279-1285.
12	Lopez-Beltra A, Requena MJ, Montironi R，et al. Plasmacytoid urothelial carcinoma of the bladder.Hum Pathol，2009，40(7):1023-1028.
13	吕自力，张文敏，肖刚，等. CD138和乙酰化肝素酶在肝细胞癌中表达的组织芯片研究.中华病理学杂志，2006，35(2):82-86.
14	朱习琴，苗建军，贾国洪，等. CD15s和CD138在胃癌中的表达及相关性研究.中国医药导报，2007，4(24):100(下转第114页).
15	涂响安，丘少鹏，邓春华，等. CD138和乙酰肝素酶在膀胱癌中的表达和临床意义.临床泌尿外科杂志，2007，22(5):337-339.
16	杨雁鸿，杨桂凤，张庆怀，等. CD138 bag-1在乳腺癌中的表达及意义.中国肿瘤临床，2008，35(1):26-30.

指标		n	CD15s			CD138
指标		n	-	＋	＋＋	阳性(%)	-	＋	＋＋	阳性(%)
性别		?	?	?	?	?	?	?	?	?
?	男	81	51	16	14	30(37.0)	43	20	18	38(46.9)
?	女	29	16	7	6	13(44.8)	16	8	5	13(44.8)
年龄(岁)		?	?	?	?	?	?	?	?	?
?	≤40	39	22	8	9	17(43.6)	24	8	7	15(38.5)
?	>40	71	45	15	11	26(36.6)	35	19	17	36(50.7)
肉眼类型		?	?	?	?	?	?	?	?	?
?	巨块型	50	28	14	8	22(44.0)	26	12	12	24(48.0)
?	结节型	43	27	7	9	16(37.2)	24	11	8	19(44.2)
?	弥漫型	17	12	2	3	5(29.4)	9	4	4	8(47.1)
肿瘤大小(cm)		?	?	?	?	?	?	?	?	?
?	≤5	37	19	10	8	18(48.6)	21	9	7	16(43.2)
?	>5	73	48	13	12	25(34.2)	38	19	16	35(47.9)
分化程度		?	?	?	?	?	?	?	?	?
?	高	43	32	6	5	11(25.6)	15	8	20	28(65.1)
?	低	67	35	17	15	32(47.8)^*	44	18	5	23(34.3)^*
转移		?	?	?	?	?	?	?	?	?
?	无	61	45	11	5	16(26.2)	23	17	21	38(62.3)
?	有	49	22	12	15	27(55.1)^△	36	11	2	13(26.5)^△

指标		n	CD15s			CD138
指标		n	-	＋	＋＋	阳性(%)	-	＋	＋＋	阳性(%)
性别		?	?	?	?	?	?	?	?	?
?	男	81	51	16	14	30(37.0)	43	20	18	38(46.9)
?	女	29	16	7	6	13(44.8)	16	8	5	13(44.8)
年龄(岁)		?	?	?	?	?	?	?	?	?
?	≤40	39	22	8	9	17(43.6)	24	8	7	15(38.5)
?	>40	71	45	15	11	26(36.6)	35	19	17	36(50.7)
肉眼类型		?	?	?	?	?	?	?	?	?
?	巨块型	50	28	14	8	22(44.0)	26	12	12	24(48.0)
?	结节型	43	27	7	9	16(37.2)	24	11	8	19(44.2)
?	弥漫型	17	12	2	3	5(29.4)	9	4	4	8(47.1)
肿瘤大小(cm)		?	?	?	?	?	?	?	?	?
?	≤5	37	19	10	8	18(48.6)	21	9	7	16(43.2)
?	>5	73	48	13	12	25(34.2)	38	19	16	35(47.9)
分化程度		?	?	?	?	?	?	?	?	?
?	高	43	32	6	5	11(25.6)	15	8	20	28(65.1)
?	低	67	35	17	15	32(47.8)^*	44	18	5	23(34.3)^*
转移		?	?	?	?	?	?	?	?	?
?	无	61	45	11	5	16(26.2)	23	17	21	38(62.3)
?	有	49	22	12	15	27(55.1)^△	36	11	2	13(26.5)^△

生存状况	n	CD15s			阳性(%)	CD138			阳性(%)
生存状况	n	-	＋	＋＋	阳性(%)	-	＋	＋＋	阳性(%)
生存者	18	12	4	2	6(33.3)	1	2	15	17(94.4)
死亡者	49	19	13	17	30(61.2)^*	26	14	9	23(46.9)^*

生存状况	n	CD15s			阳性(%)	CD138			阳性(%)
生存状况	n	-	＋	＋＋	阳性(%)	-	＋	＋＋	阳性(%)
生存者	18	12	4	2	6(33.3)	1	2	15	17(94.4)
死亡者	49	19	13	17	30(61.2)^*	26	14	9	23(46.9)^*

[1]	Miao Li, Lianhua Zhu, Peng Han, Bo Jiang, Xiang Fei. Evaluation of relationsip between vascular morphology and risk factors for hepatocellular carcinoma by high-frame-rate contrast-enhanced ultrasound [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(09): 911-915.
[2]	Jianmin Ding, Zhengyi Qin, Xiang Zhang, Yan Zhou, Hongyu Zhou, Yandong Wang, Xiang Jing. Contrast-enhanced ultrasound versus gadoxetic acid-enhanced magnetic resonance imaging for LI-RADS classification of focal liver lesions ≤3 cm in patients at high risk of hepatocellular carcinoma: a prospective study [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(09): 930-938.
[3]	Jie Dong, Song Yang, Hao Yang, Xiang Chen, Wanli Zhang. Relationship between hypermethylation of ACACB gene and clinicopathological factors and survival of hepatocellular carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(06): 433-437.
[4]	Wei Huang, Qi Liu, Liuhua Chen, Chaxiang Teng, Zhejian Ou, Hanxiao Liu, Jiancong Chen, Kunsong Zhang. Identification of a pyroptosis-related lncRNA signature as a novel prognostic biomarker for hepatocellular carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(05): 357-365.
[5]	Rongchang Wang, Qifeng Ou, Jinjie Huang, Caiqin Wang, Qian Wang, Xiaohui Huang. Expression of miR-145-5p in hepatocellular carcinoma and its clinical significance [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(03): 197-202.
[6]	Qingyan Yan, Xiaomei Yong, Hong Luo, Min Du. Prognostic factors and survival analysis of multicenter elderly patients with metastatic breast cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 636-638.
[7]	Heng Yu, Xiaofeng Lu, Peng Song, Yonghuan Mao, Feng Sun, Shichao Ai, Feng Wang, Liang Tao, Qiongyuan Hu, Meng Wang, Song Liu, Qiong Wang, Xiaofei Shen, Wenxian Guan. Analysis of risk factors for liver metastasis in gastric cancer and construction of prediction model [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(04): 375-379.
[8]	Qijian Yu, Zhe Yang, Shusen Zheng. Current status and progress of research on prevention of tumor recurrence after liver transplantation for hepatocellular carcinoma [J]. Chinese Journal of Transplantation(Electronic Edition), 2023, 17(03): 171-179.
[9]	Wenhua Zhang, Cui Tao, Tiansong Hu. Clinicopathological characteristics of pedunculated hepatocellular carcinoma in different sites and its effects on postoperative intrahepatic recurrence and prognosis [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 651-655.
[10]	Di Wang, Shaocheng Lyu, Jincan Huang. Pancreatic metastasis of lung adenocarcinoma with portal vein invasion: a case report [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(04): 457-460.
[11]	Zhao Li, Ying Zhang, Yancheng Song, Zhaopeng Li, Shuguang Liu, Dong Guo, Dong Chen, Yu Li. Construct a nomogram to predict the prognosis of patients with colorectal liver metastasis after operation [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(04): 311-318.
[12]	Baoru Hu, Naijian Shang, Di Gao. DCE-MRI and DWI findings of advanced hepatocellular carcinoma and their correlation with prognosis after immunotherapy [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 399-403.
[13]	Fengyun Wu, Xin Teng, Lianjuan Liu. Diagnostic value of high-frequency ultrasonography and enhanced magnetic resonance for primary hyperdifferentiated hepatocellular carcinoma of different diameters [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 404-408.
[14]	Zhongbai Liu, Yongjun Ren. Current status and progress of interventional therapy for hepatocellular carcinoma [J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(02): 111-115.
[15]	Xueqing Huang, Nan Wei, Tianpeng Jiang, Tianzhi An, Min Xu, Shi Zhou. Clinical study of TACE for hepatocellular carcinoma by ultrasound-guided transdistal radial artery approach [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2023, 11(03): 251-256.

Please choose a citation manager

Content to export