Treatment of pancreatic carcinoma with the combination of laparoscopic surgery and photodynamic therapy

doi:10.3877/cma.j.issn.1674-0793.2011.02.008

Abstract

Abstract:

Objective

To compare the effect of the combination of laparoscopic surgery and photodynamic therapy and other palliative therapies as an initial treatment for patients with advanced-stage pancreatic carcinoma.

Methods

Twenty-eight patients with advanced-stage pancreatic carcinoma were divided into group A and B at random. Thirteen patients in group A were undergoed the combination of laparoscopic surgery and photodynamic therapy. Meanwhile, 15 patients in group B were treated by other palliative therapies: chemotherapy, radiotherapy, stent implantation, and open abdominal surgery etc.

Results

The 0.5-, 1-, 2- year survival rates in group A and B were 92.3%, 76.9%, 12.0%, and 66.7%, 42.3%, 0%, respectively. The survival rates in group A was significantly higher than those of group B(χ²=3.923, P<0.05).

Conclusion

The combination of laparoscopic surgery and photodynamic therapy is effective to patients with advanced-stage pancreatic carcinoma.

Key words: Laparoscopy, Photodynamic therapy, Pancreatic carcinoma

Yue LI, Liang-qi CAO, He-ping PENG, Xue-wei YANG. Treatment of pancreatic carcinoma with the combination of laparoscopic surgery and photodynamic therapy[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(02): 120-123.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2011.02.008

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2011/V05/I02/120

临床指标		PDT组	对照组	P值
例数		13	15	?
年龄（岁）		67.5±14.8	60.7±14.3	0.232
?	?	35-85	32-84	?
性别		?	?	?
?	男	6	8	0.705
?	女	7	7	?
肿瘤大小（cm）		?	?	?
?	≤5	5	6	0.930
?	>5	7	9	?
CEA（ng/ml)		25.66±23.45	36.92±28.42	0.268
CA199(U/ml)		823.6±994.9	942.1±1057.7	0.769
CA125(U/ml)		80.5±60.2	94.1±74.8	0.606

临床指标		PDT组	对照组	P值
例数		13	15	?
年龄（岁）		67.5±14.8	60.7±14.3	0.232
?	?	35-85	32-84	?
性别		?	?	?
?	男	6	8	0.705
?	女	7	7	?
肿瘤大小（cm）		?	?	?
?	≤5	5	6	0.930
?	>5	7	9	?
CEA（ng/ml)		25.66±23.45	36.92±28.42	0.268
CA199(U/ml)		823.6±994.9	942.1±1057.7	0.769
CA125(U/ml)		80.5±60.2	94.1±74.8	0.606

项目		PDT组	对照组	χ²/t值	P值
例数		13	15	?	?
随访情况		?	?	1.794	0.408
?	死亡	9	13	?	?
?	失访	3	2	?	?
?	存活	1	0	?	?
生存时间（d）		97~721	59~714	t=2.472	0.02
?	平均数	556	354	?	?
?	中位数	624	541	?	?
死亡原因		?	?	6.068	0.048
?	肝肾衰竭	6	13	?	?
?	消化道大出血	2	0	?	?
?	肠梗阻	1	0	?	?
年生存率（%）		?	?	3.923	0.048
?	0.5年	92.3	66.7	?	?
?	1年	76.9	42.3	?	?
?	2年	12	0	?	?

项目		PDT组	对照组	χ²/t值	P值
例数		13	15	?	?
随访情况		?	?	1.794	0.408
?	死亡	9	13	?	?
?	失访	3	2	?	?
?	存活	1	0	?	?
生存时间（d）		97~721	59~714	t=2.472	0.02
?	平均数	556	354	?	?
?	中位数	624	541	?	?
死亡原因		?	?	6.068	0.048
?	肝肾衰竭	6	13	?	?
?	消化道大出血	2	0	?	?
?	肠梗阻	1	0	?	?
年生存率（%）		?	?	3.923	0.048
?	0.5年	92.3	66.7	?	?
?	1年	76.9	42.3	?	?
?	2年	12	0	?	?

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