The expression of N-cadherin is upregulated in epithelial malignant tumor and is associated with epithelial to mesenchymal transition.The overexpression of N-cadherin expression has been shown to promote motility and invasion. N-cadherin plays an important role in the tumorigenesis, infiltration, metastasis and angiogenesis.ADH-1 as a systemic anticancer agent can induce apoptosis of the target cells and cause tumour vascular damage,which disrupt extracellular N-cadherin adhesion, altering the association of N-cadherin and FGFR-1, and destabilized FGFR-1 to induce the expression of FGFR-1 lost, and the result was that the tumour vascular was damaged and the growth of tumor was inhibited. It providing a theoretical basis for treatment of clinical oncology.