To explore effective measurements to prevent pancreatic fistula after pancreaticoduodenectomy(PD).

The clinical information of 64 patients of PD were restrospectively analyzed. the causative factors and preventive measurements for pancreatic fistula after PD were investigated.

Of 64 patients, there were 7 cases of pancreatic fistula, 5 of whom were healed by nonsurgical treatments and 1 died of severe intraabdominal infection and MOF. The average hospital stay of pancreatic fistula patients was 35.8 days with a range of 18 to 93 days.

Sufficient preoperative preparation, proper operation modality according to texture of the pancreas and the condition of peripancreas, adequate decompression of the pancreaticoenteric anastomosis, patency of abdominal drainge in combination with intraoperative use of bioprotein gel and postoperative administration of octreotide are helpful for precaution of pancreatic fistula after PD.