Abstract:
Objective To investigate the expression of KiSS-1, MUC1 and E-cad in breast cancer and their correlations to clinicopathologic character.
Methods The expression of TLR4, NF-κB and AP-1 in 106 specimens of breast cancer were detected by immunohistochemistry, and their correlations to the clinicopathologic characteristics of breast cancer were analyzed. The correlations of TLR4 expression to NF-κB and AP-1 were analyzed by Spearman’s rank correlation.
Results The expressions of TLR4, NF-κB and AP-1 had some relation with T, M, N stages and clinical stages of breast cancer (P < 0.05), but they had no correlation with age and menopause (P > 0.05). Expressions of TLR4, NF-κB and AP-1 increased gradually with the progress of T, M, N stages and clinical stages (P < 0.05). Expressions of NF-κB increased gradually with the progress of histological grade (P < 0.05). The positive correlation was observed between TLR4 expression and AP-1 expression (r = 0.816, P < 0.05).
Conclusion TLR4 over expressed in human breast cancer can activate AP-1 signaling pathway, may promote proliferation, invasion and metastasis of breast cancer cell, and may affect the prognosis of patients.
Key words:
Breast neoplasm,
TLR4,
NF-κB,
AP-1
Bao-jun LU, Bing-zong HOU, Xiao-hong WANG, Xin-min GOU, Qing-an ZENG. Expression of TLR4 in breast cancer and its correlation to NF-κB and AP-1[J]. Chinese Archives of General Surgery(Electronic Edition), 2011, 05(06): 508-511.