Expression and clinical significance of matrix metalloproteinases-9 in pancreatic carcinoma tissues

doi:10.3877/cma.j.issn.1674-0793.2013.06.005

Abstract

Abstract:

Objective

To investigate the expression of matrix metalloproteinases-9 (MMP-9) in pancreatic carcinoma and its clinicopathological characteristics and prognosis.

Methods

The expression of MMP-9 was detected in 70 pieces of primary pancreatic carcinoma and 15 pieces of non-tumor pancreatic tissues by EliVision^TM Plus immunohistochemistry method. The relationship between MMP-9 expression and survival, clinicopathological characteristics were analyzed.

Results

The positive rate of MMP-9 in 70 pieces of primary pancreatic carcinoma tissues was 68.6% (48/70) , and that was significantly higher than that in the 15 pieces of adjacent non-tumor pancreatic tissues(26.7%, 4/15). The expression of MMP-9 did not correlate with gender, age and the tumor position, while it was significantly correlated with the tumor size, differentiation grade, TNM stages and lymph node metastasis(P<0.05). Progression-free survival and overall survival of negative group(22 cases) were significantly longer than the positive group(48 cases), χ²=11.84, 16.09 respectively, P<0.05.

Conclusions

The MMP-9 expression is closely related with clinicopathological parameters of patients with pancreatic cancer. The over-expression MMP-9 may get poor prognostic predictors.

Key words: Pancreatic carcinoma, Matrix metalloproteinases-9, Immunohistochemistry, Prognosis

Pei-zhong SHANG, Xiao-wu LI, Da-wei CAI, Wei-nan ZHAO, Yan-chun WEN, Hua-ping GU. Expression and clinical significance of matrix metalloproteinases-9 in pancreatic carcinoma tissues[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(06): 436-440.

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Figures/Tables 5

References 24

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临床病理指标		例数	MMP-9阳性[例(%)]	χ²值	P值
性别		?	?	?	?
?	男	44	29(65.9)	0.390	0.533
?	女	26	19(73.1)	?	?
年龄（岁）		?	?	?	?
?	≤60	27	18(66.7)	0.074	0.786
?	>60	43	30(69.8)	?	?
肿瘤部位		?	?	?	?
?	胰头部	42	28(66.7)	0.177	0.674
?	体尾部	28	20(71.4)	?	?
肿瘤大小（cm）		?	?	?	?
?	≤3	46	26(56.5)	9.039	0.003
?	>3	24	22(91.7)	?	?
分化程度		?	?	?	?
?	高+中	51	30(58.8)	8.285	0.004
?	低	19	18(94.7)	?	?
TNM分期		?	?	?	?
?	Ⅰ+Ⅱ	27	12(44.4)	11.872	0.001
?	Ⅲ+Ⅳ	43	36(83.7)	?	?
淋巴结转移		?	?	?	?
?	有	41	33(80.5)	6.521	0.011
?	无	29	15(51.7)	?	?

临床病理指标		例数	MMP-9阳性[例(%)]	χ²值	P值
性别		?	?	?	?
?	男	44	29(65.9)	0.390	0.533
?	女	26	19(73.1)	?	?
年龄（岁）		?	?	?	?
?	≤60	27	18(66.7)	0.074	0.786
?	>60	43	30(69.8)	?	?
肿瘤部位		?	?	?	?
?	胰头部	42	28(66.7)	0.177	0.674
?	体尾部	28	20(71.4)	?	?
肿瘤大小（cm）		?	?	?	?
?	≤3	46	26(56.5)	9.039	0.003
?	>3	24	22(91.7)	?	?
分化程度		?	?	?	?
?	高+中	51	30(58.8)	8.285	0.004
?	低	19	18(94.7)	?	?
TNM分期		?	?	?	?
?	Ⅰ+Ⅱ	27	12(44.4)	11.872	0.001
?	Ⅲ+Ⅳ	43	36(83.7)	?	?
淋巴结转移		?	?	?	?
?	有	41	33(80.5)	6.521	0.011
?	无	29	15(51.7)	?	?

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