Predictive value of preoperative examination of malignancy of thyroid nodules

doi:10.3877/cma.j.issn.1674-0793.2014.01.004

Abstract

Abstract:

Objective

To identify the risk factors that can predict the pathological diagnosis of thyroid nodules before operation, and to reduce the operation of benign nodules in all surgical nodules.

Methods

All consecutive patients with thyroid nodules who underwent surgery and had pathological diagnosis in 2011 were identified. Univariate and logistic multivariate analysis were carried out to exam the risk of malignant thyroid nodules.

Results

The proportion of pathologically malignant nodules in all nodules was 22%. Univariate and logistic multivariate analysis revealed that singles, shape, calcification, echo texture, margin and vascularity were associated with malignancy.

Conclusions

The proportion of pathologically malignant nodules in surgical nodules is relatively low, some ultrasound characteristics of thyroid nodules, called risk factors, were significant in predicting pathological diagnosis. Rational use of these risk factors can predict pathological diagnosis more accurately and reduce the proportion of benign nodules in all surgical nodules.

Key words: B-type ultrasound examination, Thyroid nodules, Prediction

Yuanhui Lai, Chen Yao, Ridong Wu. Predictive value of preoperative examination of malignancy of thyroid nodules[J]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(01): 12-15.

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References 18

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变量		良性甲状腺结节（n=1131）	恶性甲状腺结节（n=319）	t值	P值
年龄(岁)		?	?	?	?
?	中位数(范围)	48(11～94)	41(17～75)	4.137	0.275
?	标准差	14.56	11.13	4.137	0.275
性别		?	?	?	?
?	男	235	614	3.589	0.958
?	女	91	205	3.589	0.958
TSH(mU/L)		?	?	?	?
?	中位数(范围)	1.20(0.01～24)	1.46(0.0～16.73)	1.332	0.021
?	标准差	1.49	1.85	1.332	0.021
肿物大小(cm)		?	?	?	?
?	中位数(范围)	2.5(0.3～8.5)	1.2(0.4～6)	2.123	0.025
?	标准差	1.55	1.13	2.123	0.025
单发		?	?	?	?
?	否	509	96	1.023	<0.001
?	是	622	223	1.023	<0.001
形态		?	?	?	?
?	卵圆	1018	191	0.989	<0.001
?	不规则形	80	48
?	纵径大于横径	33	80
回声		?	?	?	?
?	等回声	170	58	0.845	<0.001
?	混合回声	532	70
?	低回声	429	191
钙化		?	?	?	?
?	无	678	70	1.223	<0.001
?	粗大钙化	315	38
?	细小钙化	138	211
边界		?	?	?	?
?	边界清	905	129	1.328	<0.001
?	边界不清	226	190	1.328	<0.001
血供		?	?	?	?
?	血供稀少	735	80	0.924	<0.001
?	血供丰富	257	217
?	其他	139	22

变量		良性甲状腺结节（n=1131）	恶性甲状腺结节（n=319）	t值	P值
年龄(岁)		?	?	?	?
?	中位数(范围)	48(11～94)	41(17～75)	4.137	0.275
?	标准差	14.56	11.13	4.137	0.275
性别		?	?	?	?
?	男	235	614	3.589	0.958
?	女	91	205	3.589	0.958
TSH(mU/L)		?	?	?	?
?	中位数(范围)	1.20(0.01～24)	1.46(0.0～16.73)	1.332	0.021
?	标准差	1.49	1.85	1.332	0.021
肿物大小(cm)		?	?	?	?
?	中位数(范围)	2.5(0.3～8.5)	1.2(0.4～6)	2.123	0.025
?	标准差	1.55	1.13	2.123	0.025
单发		?	?	?	?
?	否	509	96	1.023	<0.001
?	是	622	223	1.023	<0.001
形态		?	?	?	?
?	卵圆	1018	191	0.989	<0.001
?	不规则形	80	48
?	纵径大于横径	33	80
回声		?	?	?	?
?	等回声	170	58	0.845	<0.001
?	混合回声	532	70
?	低回声	429	191
钙化		?	?	?	?
?	无	678	70	1.223	<0.001
?	粗大钙化	315	38
?	细小钙化	138	211
边界		?	?	?	?
?	边界清	905	129	1.328	<0.001
?	边界不清	226	190	1.328	<0.001
血供		?	?	?	?
?	血供稀少	735	80	0.924	<0.001
?	血供丰富	257	217
?	其他	139	22

变量		OR值	95%CI	P值
单发		?	?	?
?	否	Reference	?	?
?	是	7.352	2.342～16.954	<0.001
形态		?	?	?
?	卵圆	Reference	?	?
?	不规则形	75.369	45.839～101.259	<0.001
?	纵径大于横径	100.218	67.329～189.432	<0.001
回声		?	?	?
?	等回声	Reference	?	?
?	混合回声	5.863	1.238～9.438	<0.001
?	低回声	8.235	2.371～14.833	<0.001
钙化		?	?	?
?	无	Reference	?	?
?	粗大钙化	4.117	0.943～11.238	0.002
?	细小钙化	45.649	23.438～90.344	<0.001
边界		?	?	?
?	边界清	Reference	?	?
?	边界不清	6.783	2.342～12.387	0.005
血供		?	?	?
?	血供稀少	Reference	?	?
?	血供丰富	0.563	0.122～4.372	0.025
?	其他	0.082	0.018～1.024	0.005

变量		OR值	95%CI	P值
单发		?	?	?
?	否	Reference	?	?
?	是	7.352	2.342～16.954	<0.001
形态		?	?	?
?	卵圆	Reference	?	?
?	不规则形	75.369	45.839～101.259	<0.001
?	纵径大于横径	100.218	67.329～189.432	<0.001
回声		?	?	?
?	等回声	Reference	?	?
?	混合回声	5.863	1.238～9.438	<0.001
?	低回声	8.235	2.371～14.833	<0.001
钙化		?	?	?
?	无	Reference	?	?
?	粗大钙化	4.117	0.943～11.238	0.002
?	细小钙化	45.649	23.438～90.344	<0.001
边界		?	?	?
?	边界清	Reference	?	?
?	边界不清	6.783	2.342～12.387	0.005
血供		?	?	?
?	血供稀少	Reference	?	?
?	血供丰富	0.563	0.122～4.372	0.025
?	其他	0.082	0.018～1.024	0.005

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