Abstract:
Objective To investigate lymph nodes micrometastases characteristics in gastric cardia adenocarcinoma(GCA) from the high and low incidence area in China.
Methods Lymph nodes of patients with GCA were obtained from Hainan Provincial Nongken General Hospital (low incidence area group, 48 cases) and the First Affiliated Hospital of Henan University of Science and Technology (high incidence area group, 45 cases). Micrometastases were detected by immunohistochemical staining for the markers cytokeratin 19(CK19) and CD44 variant 6(CD44v6). The data were analyzed statistically.
Results A total of 47 lymph nodes micrometastases (6.99%) from 24 patients (25.81%) were found out. The incidence of lymph nodes micrometastases was significantly different between the two groups (4.33% vs 9.46%, χ2=6.763, P=0.009). Clinical re-staging had no significant difference in the two groups (18.75% vs 33.33%, χ2=2.576, P=0.108). 87 patients were followed up, and the recurrence rate was significantly higher and survival rate was significantly lower in the positive group than in those without lymph node micrometastases (P<0.05). Recurrence rate was significantly lower in patients from the high incidence area than from the low incidence area (19.05% vs 35.56%, χ2=3.986, P=0.046).
Conclusion Detecting micrometastases is necessary in GCA patients, whether from the high or low incidence. Micrometastases might correlate with worse prognosis for patients of GCA.
Key words:
Gastric cardia adenocarcinoma,
Lymph node,
Micrometastases,
High and low incidence areas
Luo Zhang, Xiaoshan Feng, Qing Li, Fanxian Ouyang, Zhigang Lin, Chenghui Chen, Zaiyong Pan. A contrastive analysis of lymph nodes micrometastases in gastric cardia adenocarcinoma in two hospitals from southern and northern China[J]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(06): 441-445.