To investigate the requirements for an effective processing strategy for post-operative sore throat (POST) to better meet the fast-track gastrointestinal surgery needs.

With prospective, randomized, double-blind study method, 280 patients under general anesthesia for gastrointestinal surgery were randomly divided into four groups. Group A: lubricated the head of tracheal tube with paraffin oil; Group B: lubricated the head of tracheal tube with tetracaine jelly; Group C: lubricated the head of tracheal tube with tetracaine jelly and 10 mg Dexamethasone i.v; Group D: lubricated the head of tracheal tube with tetracaine jelly and 10 mg Dexamethasone + 40 mg Dynastat i.v. A blinded observer interviewed all patients on postoperative sore throat and hoarseness at 10 min, 30 min,1 h, 6 h, 12 h, 24 h after extubation.

In the 10 min observation point after extubation, the incidence of POST in group B, C, D was lower than group A (P<0.05). At the 30 min and 1 h observation points, the incidence of POST in group B、C, D was lower than group A (P<0.05); the incidence of POST in group D was lower than group C and B (P<0.05). In the 6 h observation point after extubation, the incidence of POST in group D was lower than group A (P<0.05); At the 12 h and 24 h observation points after extubation, the incidence of POST had no significant differences among groups. During PACU observation period, the incidence of suction in group C and D was lower than group A and B (P<0.05).

Multi-modal treatment of endotracheal tube lubricating composite intravenous drug can prevent POST, and intravenous injection of hormones can reduce airway secretions after extubation.