Pin1: a catalyst of the tumorigenesis of malignant neoplasms

doi:10.3877/cma.j.issn.1674-0793.2016.02.016

Abstract

Abstract:

Pin1 belongs to peptidyl-prolyl cis-trans isomerase (PPlases) family, which can specif-ically catalyze the phosphorylated Ser/Thr-Pro motif to change its cis-trans isomerism, thereby modulat-ing the conformation and function of substrtates. Previous studies have verified that Pin1 is overexpressed in 38 of 60 tumors, and it participates in many cellular signal pathways and promotes tumorigenesis as a catalyst and an amplifier. Here we make a review about the structure and function of Pin1, and the in-volvement and development in malignant neoplasms.

Key words: NIMA-interacting peptidylprolyl isomerase, Pin1, Neoplasms

Mingxiao Cao, Lixin Jiang. Pin1: a catalyst of the tumorigenesis of malignant neoplasms[J]. Chinese Archives of General Surgery(Electronic Edition), 2016, 10(02): 150-153.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2016.02.016

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2016/V10/I02/150

References 25

1	Driver JA. Understanding the link between cancer and neurode-generation[J]. J Geriatr Oncol, 2012, 3(1): 58-67.
2	Liou YC,Zhou XZ,Lu KP. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins[J]. Trends Bio-chem Sci, 2011, 36(10): 501-514.
3	Lee TH,Pastorino L,Lu KP. Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease[J]. Expert Rev Mol Med, 2011, 13:e21.
4	Wang JZ,Zhang YH,Sun XW, et al. Focusing on the structure and the function of Pin1: new insights into the opposite effects of fever on cancers and Alzheimer's disease[J]. Med Hypotheses, 2013, 81(2): 282-284.
5	Wang JZ,Li SR,Li YL, et al. Could Pin1 help us conquer essen-tial hypertension at an earlier stage? A promising early-diagnostic biomarker and its therapeutic implications for the disease[J]. Med Hypotheses, 2013, 81(5): 931-935.
6	Lu KP,Zhou XZ. The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease[J]. Nat Rev Mol Cell Bi-ol, 2007, 8(11): 904-16.
7	Lu Z,Hunter T. Prolyl isomerase Pin1 in cancer[J]. Cell research, 2014, 24(9): 1033-1049.
8	Litchfield DW,Shilton BH,Brandl CJ, et al. Pin1: intimate in-volvement with the regulatory protein kinase networks in the glob-al phosphorylation landscape[J]. Biochim Biophys Acta, 2015, 1850(10): 2077-2086.
9	Wulf GM,Ryo A,Wulf GG, et al. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the tran-scriptional activity of c-Jun towards cyclin D1[J]. EMBO J, 2001, 20(13): 3459-3472.
10	Bao L,Kimzey A,Sauter G, et al. Prevalent overexpression of pro-lyl isomerase Pin1 in human cancers[J]. Am J Pathol, 2004, 164(5): 1727-1737.
11	Ayala G,Wang D,Wulf G, et al. The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer[J]. Cancer Res, 2003, 63(19): 6244-6251.
12	Tan X,Zhou F,Wan J, et al. Pin1 expression contributes to lung cancer prognosis and carcinogenesis[J]. Cancer Biol Ther, 2010, 9(2): 111-119.
13	Shi M,Chen L,Ji J, et al. Pin1 is overexpressed and correlates with poor prognosis in gastric cancer[J]. Cell Biochem Biophys, 2015, 71(2): 857-864.
14	Lin FC,Lee YC,Goan YG, et al. Pin1 positively affects tumorigen-esis of esophageal squamous cell carcinoma and correlates with poor survival of patients[J]. J Biomed Sci, 2014, 21: 75.
15	Zhu Y,Qin L,Li M, et al. Pin1 expression affects cell proliferation and apoptosis of SW620 cells in colorectal carcinoma[J]. Chinese-German J Clin Oncol, 2011, 10(2): 100-104.
16	Zhou L,Park BH,Park JH, et al. Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells[J]. On-col Rep, 2013, 29(1): 193-198.
17	Pulikkan JA,Dengler V,Peer Zada AA, et al. Elevated PIN1 ex-pression by C/EBPalpha-p30 blocks C/EBPalpha-induced granu-locytic differentiation through c-Jun in AML[J]. Leukemia, 2010, 24(5): 914-923.
18	Lill C,Schneider S,Pammer J, et al. Significant correlation of pep-tidyl-prolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients[J]. Head & neck, 2011, 33(9): 1294-1300.
19	Ryo A,Liou YC,Wulf G, et al. PIN1 is an e2f target gene essen-tial for Neu/Ras-induced transformation of mammary epithelial cells[J]. Mol Cell Biol, 2002, 22(15): 5281-5295.
20	Lee TH,Chen CH,Suizu F, et al. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function[J]. Mol Cell, 2011, 42(2): 147-159.
21	Rangasamy V,Mishra R,Sondarva G, et al. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function[J]. Proc Natl Acad Sci U S A, 2012, 109(21): 8149-8154.
22	Girardini JE,Napoli M,Piazza S, et al. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer[J]. Cancer cell, 2011, 20(1): 79-91.
23	Girardini JE,Marotta C,Del Sal G. Disarming mutant p53 onco-genic function[J]. Pharmacol Res, 2014, 79: 75-87.
24	Wang JZ,Liu BG,Zhang Y. Pin1-based diagnostic and therapeu-tic strategies for breast cancer[J]. Pharmacol Res, 2015, 93: 28-35.
25	Moore JD,Potter A. Pin1 inhibitors: Pitfalls, progress and cellular pharmacology[J]. Bioorg Med Chem Lett, 2013, 23(15): 4283-4291.

[1]	Dan Han, Ting Wang, Huan Xiao, Lirong Zhu, Jingyu Chen, Yi Tang. Diagnostic value of contrast enhanced ultrasound versus contrast enhanced computed tomography in benign and malignant liver lesions in children [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(09): 939-944.
[2]	Yaping Jia, Shu'e Zeng. Ultrasound and pathological characteristics of breast metaplastic carcinoma containing squamous cell carcinoma components [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(08): 844-848.
[3]	Wei Tang, Rongquan He, Suning Huang. Application of deep learning in imaging for diagnosis, treatment and prognosis prediction of breast cancer [J]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(06): 323-328.
[4]	Su Yan, Bowen Huo, Huining Xu. 4K fluorescent laparoscopic extended CME plus D3 lymphadenectomy with No.206 and No.204 lymph node dissection for ascending colon cancer and hepatic flexure cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 14-14.
[5]	Hongwei Yao, Pengyu Wei, Jiale Gao, Zhongtao Zhang. Continuous improvement in the standardization of laparoscopic D3 dissection in patients undergoing laparoscopic colectomy for right colon cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 1-4.
[6]	Xiaohui Du, Jianxin Cui. The strategy of D3 lymph node dissection for laparoscopic radical right hemicolectomy on right colon cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 5-8.
[7]	Yanbing Zhou, Xiaodong Liu. Choice of digestive tract reconstruction after laparoscopic right colectomy of colon cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 9-13.
[8]	Xu Tang, Bing Han, Wei Liu, Ruxing Chen. Analysis of risk factors for metachronous liver metastases after radical colorectal cancer surgery and construction of a predictive model [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 16-20.
[9]	Shengjun Zhang, Ajing Zhao, Shoubo Li, Xianghong Hao, Minli Liu. An experimental study on the promotion of colorectal cancer invasion and migration by high glucose through HGF/c-met pathway [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 21-24.
[10]	Yanhui Zhang, Jiao Zhang, Zhixian Zhu. Effect of indwelling anal tube on anastomotic leakage after laparoscopic total mesangectomy after neoadjuvant chemoradiotherapy in patients with middle and low rectal cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 25-28.
[11]	Jianmei Li, Jingjuan Deng, Qian Yang. Safety and follow-up evaluation of the combined treatment of hepatocellular carcinoma with hepatic cirrhosis and portal hypertension [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 41-44.
[12]	Bing Pan, Shaocheng Lyu, Xin Zhao, Lixin Li, Ren Lang, Qiang He. Effect of number of dissected lymph nodes on efficacy of pancreaticoduodenectomy for distal cholangiocarcinoma [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 608-612.
[13]	Can Tang, Xiangyang Li, Haoran Qin, Jing Li, Tianyun Wang, Yang Ke, Hong Zhu. Diagnosis, treatment and efficacy analysis of 12 cases of primary hepatic neuroendocrine neoplasm: a single center study [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 674-680.
[14]	Jiaqi Cui, Di Wu, Haiyan Chen, Huimin Zhou, Yuanlong Gu, Guangwen Zhou, Jun Yang. Clinical diagnosis and treatment of liver abscess after TACE [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 688-693.
[15]	Tixian Xiao, Qian Liu, Jinghai Song. Extramammary paget disease with splenic metastasis: a case report [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 717-719.

Please choose a citation manager

Content to export