Analysis of clinical pathological features and prognosis of 18 cases of pure mucinous breast cancer

doi:10.3877/cma.j.issn.1674-0793.2017.03.008

Abstract

Abstract:

Objective

To study the clinical pathological features between the subtypes of the female mucinous breast cancer with its prognosis.

Methods

Eighteen cases confirmed as pure mucinous breast cancer (PMBC) with complete case report and follow-up information in Beijing Shijitan Hospital was collected and divided into type A PMBC and type B PMBC. A retrospective analysis was performed for both groups on clinical and pathological features and prognosis.

Results

The axillary metastasis rate for type A PMBC was 13.3%, and 0 for type B PMBC. The distant metastasis rate for type A was 6.7%, and 0 for type B. The percentage of ER and PR positive cases for type A was 93.3% and 86.7%, respectively, and was both 33.3% for type B. The HER-2 gene overexpression rate was both 0 for type A and B. And for Ki-67 expression, the low and high expression rate for type A was 80.0% and 20.0%, respectively, and was 100.0% and 0 for type B, respectively.

Conclusions

PMBC is a special subtype of the breast cancer with good prognosis. The pathological features and biological behavior between type A and type B is different. Further research and more data will be needed to access the prognosis with the classification.

Key words: Breast neoplasms, Pure mucinous breast cancer, Clinical features, Prognosis

Ying Mu, Yizhi Chen, Dapeng Lyu, Yanping Li, Yihui Guo, Xia Zhao. Analysis of clinical pathological features and prognosis of 18 cases of pure mucinous breast cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2017, 11(03): 175-178.

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References 8

[1]	Ha KY, Deleon P, Deleon W. Invasive mucinous carcinoma of the breast[J]. Proc (Bayl Univ Med Cent), 2013, 26(3):295-297.
[2]	Kashiwagi S, Onoda N, Asano Y, et al. Clinical significance of the sub-classification of 71 cases mucinous breast carcinoma[J]. Springerplus, 2013, 2:481.
[3]	Lakhani S. R., et al. WHO Classification of Tumours of the Breast. World Health Organization[M]. 2012, 7: 60-61.
[4]	Sharma S, Bansal R, Khare A, et al. Mucinous carcinoma of breast: cytodiagnosis of a case[J]. Cytol, 2011, 28(1):42-44.
[5]	Skotnicki P, Sas-Korczynska B, Strzepek L, et al. Pure and mixed mucinous varcinoma of the breast: a comparison of clinical outcomes and treatment results[J]. Breast, 2016, 22(5):529-534.
[6]	Ranade A, Batra R, Sandhu G, et al. Clinicopathological evaluation of 100 cases of mucinous carcinoma of breast with emphasis on axillary staging and special reference to a micropapillary pattern[J]. Clin Pathol, 2010, 63(12):1043-1047.
[7]	Di Saverio S, Gutierrez J, Avisar E. A retrospective review with long term follow up of 11 400 cases of pure mucinous breast carcinoma[J]. Breast Cancer Res Treat, 2008, 111(3):541-547.
[8]	Tse GM, Ma TK, Chu WC. Neuroendocrine differentiation in pure type mammary mucinous carcinoma is associated with favorable histologic and immunohistochemical parameters[J]. Mod Pathol, 2004, 17(5):568-572.

分型	例数	平均年龄（岁，±s）^a	肿瘤大小（例）			平均肿瘤直径（cm，±s）^a	腋窝淋巴结转移（例）			远处转移（例）
分型	例数	平均年龄（岁，±s）^a	≤2 cm	>2~5 cm	>5 cm	平均肿瘤直径（cm，±s）^a	0	1~3枚	4~9枚	远处转移（例）
A型	15	62.2±16.3	4	10	1	2.9±2.0	13	1	1	1
B型	3	77.1±5.3	0	1	2	7.2±4.7	3	0	0	0
统计值		2.222	3.778			0.889	0.000
P值		1.000	0.993			0.346	1.000

分型	例数	平均年龄（岁，±s）^a	肿瘤大小（例）			平均肿瘤直径（cm，±s）^a	腋窝淋巴结转移（例）			远处转移（例）
分型	例数	平均年龄（岁，±s）^a	≤2 cm	>2~5 cm	>5 cm	平均肿瘤直径（cm，±s）^a	0	1~3枚	4~9枚	远处转移（例）
A型	15	62.2±16.3	4	10	1	2.9±2.0	13	1	1	1
B型	3	77.1±5.3	0	1	2	7.2±4.7	3	0	0	0
统计值		2.222	3.778			0.889	0.000
P值		1.000	0.993			0.346	1.000

分型	例数	ER		PR		HER2		Ki-67
		阳性	阴性	阳性	阴性	阳性	阴性	低表达	高表达
A型	15	14（93.3）	1（6.7）	13（86.7）	2（13.3）	0（0）	15（100.0）	12（80.0）	3（20.0）
B型	3	1（33.3）	2（66.7）	1（33.3）	2（66.7）	0（0）	3（100.0）	3（100.0）	0（0）
χ²值		0.113		0.000		0.000		0.002
P值		0.737		1.000		1.000		1.000

分型	例数	ER		PR		HER2		Ki-67
		阳性	阴性	阳性	阴性	阳性	阴性	低表达	高表达
A型	15	14（93.3）	1（6.7）	13（86.7）	2（13.3）	0（0）	15（100.0）	12（80.0）	3（20.0）
B型	3	1（33.3）	2（66.7）	1（33.3）	2（66.7）	0（0）	3（100.0）	3（100.0）	0（0）
χ²值		0.113		0.000		0.000		0.002
P值		0.737		1.000		1.000		1.000

分型	例数	总体生存时间	平均生存时间±s	平均无病生存时间±s
A型	15	6~100	40.8±0.5	32.7±2.1
B型	3	62~112	75.3±5.4	75.3±3.7
t值			3.864	4.189
P值			0.076	0.017

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