To investigate the clinical effect of percutaneous catheter drainage (PCD) in the treatment of severe acute pancreatitis complicated with necrosis and infection.

The clinical data of one hundred and thirteen patients with SAP complicated with pancreatic necrosis and infection were retrospectively analyzed of Beijing Friendship Hospital Affiliated to Capital Medical University from June 2011 to June 2015, and 54 cases were treated with PCD as the observation group and 59 cases treated by open surgery and drainage as the control group. The operation effect of the two groups were compared.

The treatment efficiency of observation group (79.6%) was less than the control group (81.4%) (χ²=0.394, P=0.530). The hospitalization time, hospitalization expenses, death or giving up treatment rate in the observation group were significantly lower than those in the control group (P<0.05), but the difference of re-operation rate was not statistically significant between the two groups. 7 days after the operation, WBC, serum amylase, urine amylase, glucose, PCT, TNF-α, and IL-8 levels were significantly lower compared with those before operation (P<0.05), and in the observation group, serum amylase, urine amylase, glucose, PCT, TNF-α, and IL-8 level decreased more significantly than the control group (P<0.05). The complication rate of observation group (13.0%) was significantly lower than the control group (32.2%) (χ²=5.892, P=0.015). There was no significant difference in the bacterial culture results of the two groups (χ²=0.374, P=0.830).

The clinical effect is significant of percutaneous catheter drainage in the treatment of severe acute pancreatitis complicated with necrosis and infection, which can effectively improve the postoperative laboratory indexes, and is beneficial to the recovery of postoperative pancreatic function, and worthy of clinical application.