Study on the correlation between lymphovascular invasion and lymph node ratio in patients withbreast cancer

doi:10.3877/cma.j.issn.1674-0793.2018.01.007

Abstract

Abstract:

Objective

To investigate the relationship between lymphovascular invasion (LVI) and lymph node ratio (LNR) in breast cancer.

Methods

The positive rate of LVI in one hundred and eighteen breast cancer patients was detected by immunohistochemical staining with monoclonal antibody D2-40 grade CK pan immunohistochemical staining to analyze the relationship between LVI and LNR.

Results

The positive rate of LVI was 37.3% (42/118), significantly related to lymph node ration, the number of lymphatic metastasis and histological grade ( χ²=9.186, 6.996, 18.340, P=0.010, 0.030, 0.000).

Conclusion

Lymphovascular invasion can be used as an important reference index for the diagnosis of axillary lymph node metastasis of breast cancer, and the higher the lymph node ratio, the higher the incidence of lymphatic invasion.

Key words: Breast neoplasms, Lymphatic vessels, Lymphatic metastasis, Lymph node ratio, Keratinocytes

Jiabing Yao, Linjiao Jia, Pilei Si, Yi Huang, Bin Fang, Haijun Chen, Wentao Li. Study on the correlation between lymphovascular invasion and lymph node ratio in patients withbreast cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2018, 12(01): 28-31.

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Figures/Tables 4

References 14

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项目		例数	LVI阳性表达		χ²值	P值
项目		例数	例数	阳性率（%）	χ²值	P值
患侧
	左侧	60	20	33.33	0.272	0.602
	右侧	58	22	37.93
年龄（岁）
	≤50	62	22	35.48	0.001	0.979
	>50	56	20	35.71
绝经状态
	绝经前	60	21	35.00	0.273	0.601
	绝经后	58	23	39.66
切除淋巴结总数（枚）
	10~20	72	35	48.61	0.015	0.992
	>20~30	42	20	47.62
	>30	4	2	50.00
淋巴结转移个数（枚）
	0	47	10	21.28	6.996	0.030
	1~3	36	16	44.44
	>3	35	16	45.71
组织学分级
	Ⅰ+Ⅱ	93	24	25.81	18.340	0.000
	Ⅲ	25	18	72.00
LNR分类
	1	57	13	22.81	9.186	0.010
	2	36	15	41.67
	3	25	14	56.00

项目		例数	LVI阳性表达		χ²值	P值
项目		例数	例数	阳性率（%）	χ²值	P值
患侧
	左侧	60	20	33.33	0.272	0.602
	右侧	58	22	37.93
年龄（岁）
	≤50	62	22	35.48	0.001	0.979
	>50	56	20	35.71
绝经状态
	绝经前	60	21	35.00	0.273	0.601
	绝经后	58	23	39.66
切除淋巴结总数（枚）
	10~20	72	35	48.61	0.015	0.992
	>20~30	42	20	47.62
	>30	4	2	50.00
淋巴结转移个数（枚）
	0	47	10	21.28	6.996	0.030
	1~3	36	16	44.44
	>3	35	16	45.71
组织学分级
	Ⅰ+Ⅱ	93	24	25.81	18.340	0.000
	Ⅲ	25	18	72.00
LNR分类
	1	57	13	22.81	9.186	0.010
	2	36	15	41.67
	3	25	14	56.00

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