To study the effect of esmolol with different concentrations on the induction of anesthesia induced by thyroidectomy.

A total of sixty-eight thyroid patients diagnosed and surgically treated in the Second Affiliated Hospital of Xi’an Medical University from October 2016 to October 2017 were randomly divided into four groups according to the random number table: group A, group B, group C and group D, with 17 cases in each group. After induction of anesthesia, group A was given 10 ml saline, group B 0.5 mg/kg esmolol, group C 1 mg/kg esmolol, and group D 1.5 mg/kg esmolol, to observed effects of different administration of esmolol on induction of anesthesia induced by thyroid surgery under neurological monitoring.

(1) There was no significant difference in heart rate, systolic pressure and diastolic blood pressure among the four groups before induction. (2) In group A and group B, the values of heart rate 60, 180 and 300 s after intubation were significantly increased(P<0.05). The heart rate of group C 180 s and 300 s after intubation was significantly higher than that after induction (P<0.05). After intubation 300 s, the heart rate of group D was higher than that after induction (P<0.05). (3) Heart rate at intubation, 60 s and 180 s after induction in group C, D was lower than group A, while systolic pressure at intubation, 60 s after induction in group C, D was lower than group A, both with significant differences (P<0.05) . (4) In the four groups, the blood rheology after intubation was significantly higher than that after anesthesia induction (P<0.05). (5) There was significant differences in sinus bradycardia among the four groups (P<0.05). Esmolol after intubation was lower in intravenous atropine bradycardia patients with a heart rate than before intravenous atropine (P<0.05).

Esmolol can significantly inhibit abnormal reaction to anesthesia intubation cardiovascular thyroid surgery at different doses, it is worthy of attention.