To compare the clinical effects of milligant-morgant hemorrhoidectomy (M-M),procedure for prolapse and hemorrhoids (PPH) and tissue-selecting therapy (TST) in the treatment of moderate-to-severe mixed hemorrhoids.

Six hundred and seventy-five patients with moderate-to-severe mixed hemorrhoids who were admitted from January 2015 to December 2018 in Dushanzi People’s Hospital in Karamay City were divided into group M-M (238 cases), group PPH (185 cases) and group TST (252 cases) according to the surgical methods. The general surgery, postoperative pain, anal edge edema, wound hemorrhage or oozing, defecation and wound healing, incidence rate of postoperative complications, anal function at 1 month after surgery, anal appearance flatness at 6 months after surgery, incidence rates of anal incontinence and anal air and liquid leakage during follow-up were compared among the three groups.

Compared to group M-M, the intraoperative blood loss, hospital stay and hospitalization cost, postoperative pain, wound healing time and recovery time, degree of anal edema, incidence of partial incontinence and defecation sensation in group PPH and group TST were significantly lower (P<0.05). The intraoperative blood loss and hospital stay in group TST were significantly lower than those in groupPPH (P<0.05). The first defecation time, the proportion of degree Ⅲ of stool condition and anal appearance flatness both showed group TST < group PPH < group M-M (P<0.05). There were no significant differences in follow-up time, recurrence rate and no-recurrence survival time among the three groups (χ²=0.771, P=0.680).

TST has similar cure rate as M-M and PPH in the treatment of moderate-to-severe mixed hemorrhoids, but it has more significant advantages in intraoperative blood loss, hospital stay and anal appearance flatness, so as to be worthy of clinical attention.