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Chinese Archives of General Surgery(Electronic Edition) ›› 2021, Vol. 15 ›› Issue (02): 152-156. doi: 10.3877/cma.j.issn.1674-0793.2021.02.017

Special Issue:

• Review • Previous Articles     Next Articles

Research status and strategy of TCR-T cell immunotherapy for hepatocellular carcinoma

Wei Hu1, Meifang He2,()   

  1. 1. Tumor Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
    2. Surgical Laboratory, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
  • Received:2020-09-30 Online:2021-04-01 Published:2021-04-25
  • Contact: Meifang He

Abstract:

Hepatocellular carcinoma (HCC) is the main form of liver cancer, and it is difficult to achieve the desirable effect for the current clinical treatment methods. Therefore, it is urgent to explore new and effective treatment methods. T cell receptor-gene engineered T cells (TCR-T) therapy has been proved to be a great promising immunotherapy because of its successful application in solid tumors. In this review, we focus on the occurrence, development and application of TCR-T immunotherapy in HCC. Some strategies are proposed, including optimizing TCR affinity, reducing toxicity, reducing mismatch of double strand in exogenous and endogenous TCR, improving tumor microenvironment, and promoting TCR-T cell expansion.

Key words: Immunotherapy, TCR-T, Hepatocellular carcinoma

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