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Chinese Archives of General Surgery(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (01): 29-33. doi: 10.3877/cma.j.issn.1674-0793.2024.01.005

• Original Article • Previous Articles    

Causal relationship between appendicectomy and colorectal anal canal malignancy: A two-sample Mendelian randomization study

Bin Niu, Lanying Rao, Hazikenni Nadila·, Longlin He, Xiaochen Liu, Bo Jiang()   

  1. Department of Gastrointestinal Surgery, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China
    Medical Office of Zhuhai No.3 Middle School, Zhuhai 519000, China
  • Received:2023-10-01 Online:2024-02-01 Published:2024-02-04
  • Contact: Bo Jiang

Abstract:

Objective

To reveal the causal association between appendicectomy and colorectal anal canal malignancies, by conducting a two-sample Mendelian randomization (MR) analysis using Genome Wide Association Study (GWAS).

Methods

The single nucleotide polymorphism (SNP) data associated with appendectomy and colorectal anal malignancies were obtained from publicly published biological databases such as UK Biobank and GWAS catalog, and all aggregated data based on GWAS were analyzed. Genetic loci closely associated with appendectomy were selected as instrumental variables. MR-Egger regression method, weighting median method, inverse variance weighting method were used to make two-sample MR, and P-value was used to evaluate the causal relationship between appendectomy and the risk of colorectal and anal canal malignancy.

Results

15 SNP loci related to appendicectomy were screened, including rs106520, rs10829663, rs10849448, rs142069498, rs21525, rs2171591, rs224029, rs2326394, rs2780304, rs34236350, rs56259011, rs72827881, rs7649870, rs76896900, rs815430. Three MR analysis methods revealed that there was no causal relationship between appendicectomy and colorectal anal canal malignancies. The heterogeneity and overall pleiotropy between data were not significant (P>0.05).

Conclusion

There is no causal relationship between appendicectomy and colorectal anal canal malignancies.

Key words: Appendicectomy, Colorectal malignancy, Anal malignancy, Mendelian randomization, Single nucleotide polymorphism

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