Photodynamic therapy of cholangiocarcinoma

doi:10.3877/cma.j.issn.1674-0793.2024.01.015

Abstract

Abstract:

Changiocarcinoma, insidious and highly malignant, is usually at the advanced stage when it is found out, and patients have lost the chance of radical surgical resection. For the palliative treatment of advanced cholangiocarcinoma, traditional methods include biliary stent placement, radiofrequency ablation, chemoradiotherapy and so on, but cholangiocarcinoma is not sensitive to chemoradiotherapy. In recent years, photodynamic therapy (PDT) has become another option for patients with advanced cholangiocarcinoma due to less trauma and adverse effects. It has been gradually applied to the palliative treatment of advanced cholangiocarcinoma and has achieved good results, thus attracts wide attention in the academic community. This paper summarizes the principles, advantages and disadvantages of the application of PDT for changiocarcinoma.

Key words: Photodynamic therapy, Cholangiocarcinoma, Biliary stent, Chemotherapy

Bin Gao, Nuertayi Amantayi·, Jianghong Ning, Yingmei Shao. Photodynamic therapy of cholangiocarcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(01): 76-80.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2024.01.015

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2024/V18/I01/76

References 33

[1]	Valery PC, Laversanne M, Clark PJ, et al. Projections of primary liver cancer to 2030 in 30 countries worldwide[J]. Hepatology, 2018, 67(2): 600-611.
[2]	Patel AH, Harnois DM, Klee GG, et al. The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis[J]. Am J Gastroenterol, 2000, 95(1): 204-207.
[3]	Höblinger A, Gerhardt T, Gonzalez-Carmona MA, et al. Feasibility and safety of long-term photodynamic therapy (PDT) in the palliative treatment of patients with hilar cholangiocarcinoma[J]. Eur J Med Res, 2011, 16(9): 391-395.
[4]	Lu Y, Liu L, Wu JC, et al. Efficacy and safety of photodynamic therapy for unresectable cholangiocarcinoma: A meta-analysis[J]. Clin Res Hepatol Gastroenterol, 2015, 39(6): 718-724.
[5]	Donohoe C, Senge MO, Arnaut LG, et al. Cell death in photodynamic therapy: from oxidative stress to anti-tumor immunity[J]. Biochim Biophys Acta Rev Cancer, 2019, 1872(2): 188308.
[6]	袁耒, 邹志强, 李传海, 等. 早期食管癌的光动力治疗[J/CD]. 中华消化病与影像杂志（电子版）, 2022, 12(5): 306-309.
[7]	Dichiara M, Prezzavento O, Marrazzo A, et al. Recent advances in drug discovery of phototherapeutic non-porphyrinic anticancer agents[J]. Eur J Med Chem, 2017, 142: 459-485.
[8]	Obaid G, Broekgaarden M, Bulin AL, et al. Photonanomedicine: A convergence of photodynamic therapy and nanotechnology[J]. Nanoscale, 2016, 8(25): 12471-12503.
[9]	Li Z, Jiang X, Xiao H, et al. Long-term results of ERCP- or PTCS-directed photodynamic therapy for unresectable hilar cholangiocarcinoma[J]. Surg Endosc, 2021, 35(10): 5655-5664.
[10]	Brunaldi VO, Brunaldi JE, Vollet-Filho JD, et al. Photodynamic therapy of extrahepatic cholangiocarcinoma using digital cholangioscopy[J]. Arq Bras Cir Dig, 2020, 33(1): e1490.
[11]	Talreja JP, DeGaetani M, Sauer BG, et al. Photodynamic therapy for unresectable cholangiocarcinoma: contribution of single operator cholangioscopy for targeted treatment[J]. Photochem Photobiol Sci, 2011, 10(7): 1233-1238.
[12]	Choi HJ, Moon JH, Ko BM, et al. Clinical feasibility of direct peroral cholangioscopy-guided photodynamic therapy for inoperable cholangiocarcinoma performed by using an ultra-slim upper endoscope (with videos)[J]. Gastrointest Endosc, 2011, 73(4): 808-813.
[13]	Zhou J, Xiong L, Liu W, et al. SpyGlass-guided photodynamic therapy for unresectable cholangiocarcinoma: A case report and review of the literature[J]. Front Oncol, 2022, 12: 890735.
[14]	Choi JH, Oh D, Lee JH, et al. Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter[J]. Endoscopy, 2015, 47(11): 1035-1038.
[15]	宋铭杰, 韩青雷, 李佳隆, 等. 内镜下晚期肝外胆管恶性肿瘤消融治疗研究现况[J/CD]. 中华普外科手术学杂志（电子版）, 2023, 17(3): 340-342.
[16]	Pereira SP, Jitlal M, Duggan M, et al. PHOTOSTENT-02: porfimer sodium photodynamic therapy plus stenting versus stenting alone in patients with locally advanced or metastatic biliary tract cancer[J]. ESMO Open, 2018, 3(5): e000379.
[17]	许博, 席大勇, 蒲唯高, 等. 双金属支架联合光动力治疗及靶向、免疫治疗在远端胆管癌中的应用[J]. 肝胆胰外科杂志, 2021, 33(7): 427-433.
[18]	Moole H, Tathireddy H, Dharmapuri S, et al. Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis[J]. World J Gastroenterol, 2017, 23(7): 1278-1288.
[19]	Mohan BP, Chandan S, Khan SR, et al. Photodynamic therapy (PDT), radiofrequency Ablation (RFA) with biliary stents in palliative treatment of unresectable extrahepatic cholangiocarcinoma: A systematic review and meta-analysis[J]. J Clin Gastroenterol, 2022, 56(2): e153-e160.
[20]	Song S, Gong S, Lei T, et al. Comparative efficacy and safety of local palliative therapeutics for unresectable malignant biliary obstruction: A Bayesian network meta-analysis[J]. Expert Rev Gastroenterol Hepatol, 2022, 16(6): 555-567.
[21]	Schmidt A, Bloechinger M, Weber A, et al. Short-term effects and adverse events of endoscopically applied radiofrequency ablation appear to be comparable with photodynamic therapy in hilar cholangiocarcinoma[J]. United European Gastroenterol J, 2016, 4(4): 570-579.
[22]	Beltrán Hernández I, Yu Y, Ossendorp F, et al. Preclinical and clinical evidence of immune responses triggered in oncologic photodynamic therapy: clinical recommendations[J]. J Clin Med, 2020, 9(2): 333.
[23]	Yu Y, Wang N, Wang Y, et al. Photodynamic therapy combined with systemic chemotherapy for unresectable extrahepatic cholangiocarcinoma: A systematic review and meta-analysis[J]. Photodiagnosis Photodyn Ther, 2023, 41: 103318.
[24]	Wentrup R, Winkelmann N, Mitroshkin A, et al. Photodynamic therapy plus chemotherapy compared with photodynamic therapy alone in hilar nonresectable cholangiocarcinoma[J]. Gut Liver, 2016, 10(3): 470-475.
[25]	Gonzalez-Carmona MA, Bolch M, Jansen C, et al. Combined photodynamic therapy with systemic chemotherapy for unresectable cholangiocarcinoma[J]. Aliment Pharmacol Ther, 2019, 49(4): 437-447.
[26]	卢学敏, 刘黎, 许泓, 等. 光化学内化作用及其在基因输送中的应用[J]. 上海交通大学学报（医学版）, 2018, 38(3): 353-356.
[27]	Trojan J, Hoffmeister A, Neu B, et al. Photochemical internalization of gemcitabine is safe and effective in locally advanced inoperable cholangiocarcinoma[J]. Oncologist, 2022, 27(6): e430-e433.
[28]	Wiedmann M, Caca K, Berr F, et al. Neoadjuvant photodynamic therapy as a new approach to treating hilar cholangiocarcinoma: A phase Ⅱ pilot study[J]. Cancer, 2003, 97(11): 2783-2790.
[29]	Wagner A, Wiedmann M, Tannapfel A, et al. Neoadjuvant down-sizing of hilar cholangiocarcinoma with photodynamic therapy--long-term outcome of a phase Ⅱ pilot study[J]. Int J Mol Sci, 2015, 16(11): 26619-26628.
[30]	Grendar J, Grendarova P, Sinha R, et al. Neoadjuvant therapy for downstaging of locally advanced hilar cholangiocarcinoma: A systematic review[J]. HPB (Oxford), 2014, 16(4): 297-303.
[31]	Sapisochin G, de Lope CR, Gastaca M, et al. Intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma in patients undergoing liver transplantation: A Spanish matched cohort multicenter study[J]. Ann Surg, 2014, 259(5): 944-952.
[32]	Vilchez V, Shah MB, Daily MF, et al. Long-term outcome of patients undergoing liver transplantation for mixed hepatocellular carcinoma and cholangiocarcinoma: An analysis of the UNOS database[J]. HPB (Oxford), 2016, 18(1): 29-34.
[33]	Cosgrove ND, Al-Osaimi AM, Sanoff HK, et al. Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation[J]. Am J Transplant, 2014, 14(2): 466-471.

Please choose a citation manager

Content to export