Advances in the role of NLRP3 inflammasome in acute pancreatitis

doi:10.3877/cma.j.issn.1674-0793.2024.04.013

Abstract

Abstract:

Acute pancreatitis (AP) is a gastrointestinal disease closely associated with inflammatory response. The NLRP3 inflammasome is a protein complex, which plays a crucial role in the development of inflammatory storms and the regulation of inflammatory states. NLRP3 inflammasome affects the occurrence, development and outcome of AP by activating oxidative stress, regulating intestinal flora and driving cellular pyroptosis, and it is expected to become a biomarker and therapeutic target for the diagnosis of AP. The current state of research on the relationship between NLRP3 inflammasome and AP and the mechanism of their interaction are summarized.

Key words: NLR family, pyrin domain-containing 3 protein, NLRP3 inflammasome, Acute pancreatitis, Oxidative stress, Intestinal flora, Pyroptosis

Jiaxing Li, Yiwen Sun, Wenxing Li. Advances in the role of NLRP3 inflammasome in acute pancreatitis[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(04): 300-304.

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