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Chinese Archives of General Surgery(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (01): 61-65. doi: 10.3877/cma.j.issn.1674-0793.2025.01.011

• Review • Previous Articles     Next Articles

Roles of adiponectin in colorectal cancer

Jinjin Hao1, Huanhuan Wang1, Shaoxiang Zheng1, Wenliang Chen2,()   

  1. 1.Graduate Department of Shanxi Medical University, Taiyuan 030001, China
    2.Department of General Surgery, the Second Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2024-05-24 Online:2025-02-01 Published:2025-02-20
  • Contact: Wenliang Chen

Abstract:

Adiponectin is a multifunctional protein secreted by adipocytes, playing a crucial role in the energy metabolism and cancer development.In recent years, numerous studies have revealed close association between low levels of adiponectin and the occurrence and progression of colorectal cancer.Adiponectin binds to its receptors and regulates various biological behaviors of colorectal cancer cells, such as survival, apoptosis, metastasis, and adhesion, through pathways like AMPK, STAT3, and PI3K/Akt.It is considered to have anti-cancer potential.Therefore, understanding the mechanisms of adiponectin in colorectal cancer is of great significance for the prevention and treatment of tumors.This review aims to summarize and elucidate the roles of adiponectin in the occurrence and progression of colorectal cancer, with a focus on its anti-cancer mechanisms.

Key words: Adiponectin, Colorectal neoplasms, Signaling transduction, Mechanisms

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