Abstract:

Hepatocellular carcinoma （HCC） is the most common primary malignant tumor of the liver， and its complex pathogenesis has been the focus of researches. With the in-depth exploration of the interaction between metabolic dysfunction and tumor immune microenvironment， there is increasing evidence that they play a key role in tumor evolution， immune escape， and immunotherapy response.Metabolic dysfunction involves a variety of biochemical processes such as glycolysis， amino acid metabolism，which are often abnormal in tumor cells to meet the energy and material requirements of rapid growth and proliferation. At the same time， these metabolic abnormalities also affect immune cells in the tumor microenvironment， thus affecting their immune response and anti-tumor activity. In recent years， a number of reports have revealed the importance of metabolic dysfunction in regulating immune cell function， immune escape mechanism and anti-tumor immune response in the immune microenvironment of HCC. However，there is still lack of systematic review and in-depth analysis of how metabolic dysfunction affecting the cellular components and functions of the HCC immune microenvironment. This study summarizes the latest research progress on the interaction between metabolic dysfunction and HCC immune microenvironment，explores its potential application in immunotherapy， proposes possible metabolic targets， and provides new directions and ideas for future HCC treatment.

Key words: Metabolic dysfunction, Metabolic networks and pathways, Carcinoma，hepatocellular, Immune microenvironment, Tumor escape, Immunotherapy