To study fast track anesthesia with desflurane combined morphine for laparoscopic cholecystectomy (LC).

Ninety patients with ASA Ⅰ-Ⅱ grade underwent LC were randomly divided into three groups: group P (propofol + remifentanil), group S(sevoflurane + remifentanil) and group D (desflurane + morphine), treatment was the same in each groups before and induction of anesthesia. maintain of anesthesia: intravenous infusion of propofol, remifentanil and cisatracurium in group P; inhalation of sevoflurane and intravenous infusion of remifentanil, no additional cisatracurium in group S; inhalation of desflurane and intravenous injection of morphine, no additional cisatracurium in group. D. Intraoperative hemodynamic fluctuations and respiratory recovery, extubation time, the time away from PACU, the incidence of intraoperative awareness and restlessness score were assessed.

The number of cases with blood pressure and heart rate fluctuations in group D and group S was significantly less than in group P(P < 0.05); the time of respiratory recovery and away from PACU in group D were less than group P and group S(P < 0.05). There was no intraoperative awareness in each group the restlessness score in group D was better than group S and group P (P < 0.05).

Fast track anesthesia with desflurane combined morphine in laparoscopic cholecystectomy can provide small hemodynamic fluctuations and high quality postoperative recovery to patients.