Effects of 2-deoxy-D-glucose and 5-Fu on proliferation and apoptosis of human gastric cancer MGC-803 cells

doi:10.3877/cma.j.issn.1674-0793.2013.05.004

Abstract

Abstract:

Objective

To investigate the effects of 2-deoxy-D-glucose ( 2-DG) or 5-Fu alone and the combination of both on the proliferation and apoptosis of human gastric cancer MGC-803 cells.

Methods

Human gastric cancer MGC-803 cells were treated with 2-DG or 5-Fu alone, or both. The inhibitory effect on the proliferation of MGC-803 cells was detected by MTT method. Apoptotic rate was assayed by flow cytometry.

Results

2-DG or 5-Fu inhibited the growth of MGC-803 cells obviously and induced the apoptosis. When 2-DG and 5-Fu were combined, the inhibitory effect and apoptotic rate were improved (P<0.05).

Conclusions

2-DG inhibits the growth of human gastric cancer MGC-803 cells. The combination of 2-DG and 5-Fu improves the ability of 5-Fu to attack the tumor cells.

Key words: 2-deoxy-D-glucose, Gastric cancer, Apoptosis

Fei-ran ZHANG, Wei LI, Yang ZHENG, Jun-tian CHEN. Effects of 2-deoxy-D-glucose and 5-Fu on proliferation and apoptosis of human gastric cancer MGC-803 cells[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(05): 347-349.

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URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2013.05.004

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