Clinical significance of lymph node micrometastasis detection in determining the stage of gastric cardia adenocarcinoma

doi:10.3877/cma.j.issn.1674-0793.2013.05.011

Abstract

Abstract:

Objective

To evaluate the significance of lymph node micrometastasis in determining the stage of gastric cardia adenocarcinoma(GCA).

Methods

Three hundred and twenty-three lymph nodes from 48 GCA patients with negative lymph node by routine pathological examination were examined immunohistochemically(IHC) for the lymph nodes micrometastasis using anti-CK19 and anti-CD44v6 monoclonal anti-body. Clinical data were analyzed by statistical methods.

Results

Micrometastasis was found in 14 lymph nodes (4.33%) from 9 cases (18.75%). Nine of those patients were up-staged(from stageⅠA toⅠB in one patient, stageⅠB to ⅡA in three patients, stageⅡA to ⅡB in three patients, stageⅡA to ⅢA in one patient, stageⅡB to ⅢB in one patient). The rate of restaging was 18.75%.

Conclusion

IHC assay can increase the detection rate of lymph node metastasis and has a significant impact on the staging of GCA.

Key words: Gastric cardia adenocarcinoma, Lymph node, Micrometastasis, Neoplasm staging

Luo ZHANG, Qing LI, Fan-xian OUYANG, Zhi-gang LIN, Cheng-hui CHEN. Clinical significance of lymph node micrometastasis detection in determining the stage of gastric cardia adenocarcinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(05): 374-377.

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Figures/Tables 4

References 10

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序号	肿瘤大小(cm)	分化程度	侵润深度	Lauren分型	TNM分期
1	2	中	T2	肠型	ⅠB→ⅡA
2	4	中	T2	弥漫型	ⅠB→ⅡA
3	3	高	T1	肠型	ⅠA→ⅠB
4	6	低	T3	弥漫型	ⅡA→ⅡB
5	8	低	T3	弥漫型	ⅡA→ⅢA
6	5.5	高	T3	肠型	ⅡA→ⅡB
7	3.5	低	T4	弥漫型	ⅡB→ⅢB
8	5	中	T2	弥漫型	ⅠB→ⅡA
9	2	低	T3	弥漫型	ⅡA→ⅡB

序号	肿瘤大小(cm)	分化程度	侵润深度	Lauren分型	TNM分期
1	2	中	T2	肠型	ⅠB→ⅡA
2	4	中	T2	弥漫型	ⅠB→ⅡA
3	3	高	T1	肠型	ⅠA→ⅠB
4	6	低	T3	弥漫型	ⅡA→ⅡB
5	8	低	T3	弥漫型	ⅡA→ⅢA
6	5.5	高	T3	肠型	ⅡA→ⅡB
7	3.5	低	T4	弥漫型	ⅡB→ⅢB
8	5	中	T2	弥漫型	ⅠB→ⅡA
9	2	低	T3	弥漫型	ⅡA→ⅡB

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