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Chinese Archives of General Surgery(Electronic Edition) ›› 2013, Vol. 07 ›› Issue (05): 397-399. doi: 10.3877/cma.j.issn.1674-0793.2013.05.016

Special Issue:

• Review • Previous Articles     Next Articles

Targeting mitophagy for the treatment of liver diseases

Chao-chen WANG1, Pei-jian ZHANG1   

  1. 1. General Surgery, Yangzhou No.1 People's Hospital, the Second Clinical Medical College, Yangzhou 225002, China
  • Received:2013-05-19 Online:2013-10-01 Published:2013-10-01

Abstract:

Autophagy is a lysosomal degradation pathway that can degrade bulk cytoplasm and superfluous or damaged organelles, such as mitochondria, to maintain cellular homeostasis. It is known that dysregulation of mitochondrial autophagy can cause pathogenesis of numerous human diseases. Here, we discuss the critical roles that mitochondrial autophagy plays in the pathogenesis of liver diseases such as non-alcoholic and alcoholic fatty liver, liver cancer, and hepatic ischemia reperfusion injury.

Key words: Mitochondrial autophagy, Nonalcoholic fatty liver disease, Liver cancer, Ischemia-reperfusion injury

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