Dietary intake of n-3 fatty acids and colorectal cancer risk: a meta analysis

doi:10.3877/cma.j.issn.1674-0793.2014.03.016

Abstract

Abstract:

Objective

A meta analysis was conducted to examine the association between the dietary intake of n-3 fatty acids and colorectal cancer risk.

Methods

Articles published from Jan 1995 to May 2013 were identified through PubMed, EMBASE, CNKI and Cochrane Library database, and relevant references of the included studies were also retrieved. Two authors independently reviewed articles, extracted data and assessed the methodological quality. Meta-analyses were conducted by using STATA 11.0 software.

Results

A total of 7 case-control studies and 4 prospective cohort studies involving 253 479 participants were included. The pooled relative risks for the highest compared with the lowest n-3 fatty acids dietary intake were 0.88 (95% CI: 0.68-1.13; P=0.316, quartiles of intake, 6 studies) and 1.03 (95% CI: 0.92-1.16; P=0.606, quintile of intake, 5 studies) for colorectal cancer risk.

Conclusions

There is insufficient evidence to suggest a significant association between dietary intake of n-3 fatty acids and colorectal cancer incidence. The effect of dietary supplementation with n-3 fatty on colorectal cancer risk needs further investigation.

Key words: n-3 fatty acids, Colorectal cancer risk, Dietary fat, Meta-analysis

Kaitao Yuan, Zhanqiang Zhang, Weidong Feng, Yingying Shi, Miao Yu, Chunlei Hu, Hanping Shi, Honglan Yu. Dietary intake of n-3 fatty acids and colorectal cancer risk: a meta analysis[J]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(03): 245-249.

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Figures/Tables 5

References 15

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纳入研究（年）	国家	实验设计	样本量（例）	发病例数	随访时间（年）	性别
Hall等（2008）^[3]	美国	前瞻性队列	22 071	500	1982-2004	男
Murff等(2009)^[4]	中国	前瞻性队列	73 242	396	1996-2000	女
Daniel等(2009)^[5]	美国	前瞻性队列	99 080	869	1999-2005	男、女
Lin等(2004)^[6]	美国	前瞻性队列	37 547	202	1993-2003	女
Nkondjock等(2002)^[7]	加拿大	病例对照	1 070	402	1989-1993	男、女
Slattery等(1997)^[8]	美国	病例对照	4 403	1 993	1991-1994	男、女
Theodoratou等(2007)^[9]	英国	病例对照	2 910	1 455	1999-2006	男、女
Kato等(2010)^[10]	美国	病例对照	2 664	1 163	2003-2005	男、女
Kim等(2009)^[11]	美国	病例对照	1 872	929	2001-2006	男、女
Kimura等(2007)^[12]	日本	病例对照	1 575	782	2000-2003	男、女
Tavani等(2003)^[13]	意大利、瑞士	病例对照	7 045	2 280	1991-2001	男、女

纳入研究（年）	国家	实验设计	样本量（例）	发病例数	随访时间（年）	性别
Hall等（2008）^[3]	美国	前瞻性队列	22 071	500	1982-2004	男
Murff等(2009)^[4]	中国	前瞻性队列	73 242	396	1996-2000	女
Daniel等(2009)^[5]	美国	前瞻性队列	99 080	869	1999-2005	男、女
Lin等(2004)^[6]	美国	前瞻性队列	37 547	202	1993-2003	女
Nkondjock等(2002)^[7]	加拿大	病例对照	1 070	402	1989-1993	男、女
Slattery等(1997)^[8]	美国	病例对照	4 403	1 993	1991-1994	男、女
Theodoratou等(2007)^[9]	英国	病例对照	2 910	1 455	1999-2006	男、女
Kato等(2010)^[10]	美国	病例对照	2 664	1 163	2003-2005	男、女
Kim等(2009)^[11]	美国	病例对照	1 872	929	2001-2006	男、女
Kimura等(2007)^[12]	日本	病例对照	1 575	782	2000-2003	男、女
Tavani等(2003)^[13]	意大利、瑞士	病例对照	7 045	2 280	1991-2001	男、女

纳入研究（年）	实验设计	选择	可比性	结局/暴露	总分
Hall等（2008）^[3]	前瞻性队列	☆☆	☆	☆☆☆	6
Murff等(2009)^[4]	前瞻性队列	☆☆☆	☆	☆☆☆	7
Daniel等(2009)^[5]	前瞻性队列	☆☆☆	☆	☆☆☆	7
Lin等(2004)^[6]	前瞻性队列	☆☆☆	☆	☆☆☆	7
Nkondjock等(2002)^[7]	病例对照	☆☆	☆☆	☆	5
Slattery等(1997)^[8]	病例对照	☆☆	☆	☆☆☆	6
Theodoratou等(2007)^[9]	病例对照	☆☆☆	☆☆	☆	6
Kato等(2010)^[10]	病例对照	☆☆	☆☆	☆	5
Kim等(2009)^[11]	病例对照	☆☆☆	☆☆	☆	5
Kimura等(2007)^[12]	病例对照	☆☆☆☆	☆☆	☆	7
Tavani等(2003)^[13]	病例对照	☆☆☆	☆	☆	5

纳入研究（年）	实验设计	选择	可比性	结局/暴露	总分
Hall等（2008）^[3]	前瞻性队列	☆☆	☆	☆☆☆	6
Murff等(2009)^[4]	前瞻性队列	☆☆☆	☆	☆☆☆	7
Daniel等(2009)^[5]	前瞻性队列	☆☆☆	☆	☆☆☆	7
Lin等(2004)^[6]	前瞻性队列	☆☆☆	☆	☆☆☆	7
Nkondjock等(2002)^[7]	病例对照	☆☆	☆☆	☆	5
Slattery等(1997)^[8]	病例对照	☆☆	☆	☆☆☆	6
Theodoratou等(2007)^[9]	病例对照	☆☆☆	☆☆	☆	6
Kato等(2010)^[10]	病例对照	☆☆	☆☆	☆	5
Kim等(2009)^[11]	病例对照	☆☆☆	☆☆	☆	5
Kimura等(2007)^[12]	病例对照	☆☆☆☆	☆☆	☆	7
Tavani等(2003)^[13]	病例对照	☆☆☆	☆	☆	5

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