Abstract:
Objective To investigate the necessity, operational indication, operation time and operation details of two-stage resection of inoperable hepatocellular cancer after regional chemoinfusion therapy.
Methods From February 2004 to September 2010, eight patients with inoperable hepatocellular cancer accepted two-stage resection after regional chemoinfusion via IDDS(implanted drug-delivery system) in hepatic artery and portal vein.
Results All the two-stage resections were schemed 20-46 days (average: 34.5±4.6) after the last regional chemoinfusion. Patients received 3-6 preoperative regimens(average: 4.2±1.6). Cancer cells were found in all the specimens from 8 patients. The center of tumor was necrotized and became fish-like, yellow brown or dark brown, with thickened pseudo-membrane and focal cancer cells alive near the margin. The average diameter of resected cancer was (5.6±2.3) cm, and the survival rates of 1-, 2-, 3-year were 87.5%, 62.5% and 50.0%.
Conclusion The regional chemoinfusion therapy is an effective way to improve the rate of resection and prolong the survival time of advanced hepatocellular cancer. The two-stage resection is schemed after 3-6 regimens of chemotherapy and 1month after the last regimen.
Key words:
Hepatocellular cancer,
Inoperable,
Regional chemoinfusion therapy,
Two-stage resection
Yong Hu, Junping Peng, Aixiang Liu, Hui Zhang, Lang Tian, Xielin Feng. Resection of inoperable hepatocellular cancer after regional chemoinfusion[J]. Chinese Archives of General Surgery(Electronic Edition), 2014, 08(04): 298-301.