Ultrasound features comparison between anaplastic thyroid carcinoma and papillary thyroid car-cinoma

doi:10.3877/cma.j.issn.1674-0793.2016.01.011

Abstract

Abstract:

Objective

To discuss the differences of ultrasound features between anaplastic thy-roid carcinoma and papillary thyroid carcinoma.

Methods

Patients were selected from January 2010 to June 2015 in our hospital for treatment and twelve patients with pathologically confirmed anaplastic thy-roid cancer as the observation group, another 35 cases over the same period with pathologically confirmed papillary thyroid carcinoma were selected as the control group. Clinical features and ultrasound character-istics of the two groups were analyzed.

Results

Women accounted for a large proportion of patients with thyroid cancer. Mean diameter of the disease was greater in anaplastic thyroid cancer patients, who were more likely to be lesions ratio <1, had higher micro calcification, less blood irregularity, more ultra-sound echo uniformity, and more blurred boundaries; all the above differences were statistically signifi-cant (P<0.05) . Characteristics of the two groups of patients with lesions in ultrasound morphology, vari-ants, echo, and contrast cystic capsule invasion were not statistically significant.

Conclusions

Thyroid cancer is female-dominated. Anaplastic thyroid cancer patients are generally with undifferentiated aspect ratios <1 and have a higher degree of microcalcifications, less irregular blood flow, more ultrasound echo uniformity, more fuzzy boundary characteristics, which is worthy of reference.

Key words: Thyroid neoplasms, Carcinoma, papillary, Ultrasonography

Qun Liu. Ultrasound features comparison between anaplastic thyroid carcinoma and papillary thyroid car-cinoma[J]. Chinese Archives of General Surgery(Electronic Edition), 2016, 10(01): 56-58.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhptwkxwx.cma-cmc.com.cn/EN/10.3877/cma.j.issn.1674-0793.2016.01.011

https://zhptwkxwx.cma-cmc.com.cn/EN/Y2016/V10/I01/56

Figures/Tables 2

References 13

1	Kebebew E,Greenspan FS,Clark OH, et al. Anaplastic thyroid carcinoma. Treatment outcome and prognostic factors[J]. Cancer, 2005, 103(7): 1330-1335.
2	温群,孟凡华,蒋培,等. CT灌注成像在甲状腺良恶性结节诊断中的应用价值[J/CD].中华临床医师杂志:电子版, 2015, 9(20): 3814-3817.
3	Nuocera C,Nehs MA,Nagarkatti SS, et al. Targeting BRAFV600E with PLX4720 displays a potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer[J]. Oncolo-gist, 2011, 16(3): 296-309.
4	Hee JS,Hee JM,Jin YK, et al. Anaplastic thyroid cancer: ultraso-nographic findings and the role of ultrasonography-guided fine needle aspiration biopsy[J]. Yonsei Med J, 2013, 54(6): 1400-1406.
5	徐新征,王晓岩.彩色多普勒超声诊断甲状腺癌的临床研究[J].河北医学, 2015, 20(7): 1165-1166.
6	罗长锐,李泉水,李振洲,等.甲状腺结节声晕对甲状腺癌的诊断价值[J].中国超声医学杂志, 2013, 29(2): 103-105.
7	荆凡静,梁智勇,龙文,等.儿童及青少年分化型甲状腺癌的侵袭特征[J].中国医学科学院学报, 2013, 35(1): 80-83.
8	甘云凤,刘纯.自身免疫性甲状腺病与甲状腺癌的相关性研究进展[J].实用医学杂志, 2013, 29(7): 1185-1189.
9	Wu G,Zhou Z,Li T, et al. Do hyperechoic thyroid nodules on B-ultrasound represent calcification[J]. J Int Med Res, 2013, 41(3): 848-854.
10	Li F,Luo H. Comparative study of thyroid puncture biopsy guid-ed by contrast-enhanced ultrasonography and conventional ultra-sound[J]. Exp Ther Med, 2013, 5(5): 1381-1384.
11	周黎光,张华伟,梁波,等.不同类型钙化在甲状腺结节良恶性诊断中的价值[J].中国现代普通外科进展, 2013, 16(12): 947-949.
12	张艳,唐杰,李民,等.甲状腺弥漫性病变合并甲状腺癌的超声诊断价值[J].中国医学科学院学报, 2015, 37(3): 289-293.
13	初海迪,郑海涛,陈剑,等.甲状腺乳头状癌B-RafV600E基因突变的临床病理因素研究[J/CD].中华普外科手术学杂志:电子版, 2015, 9(3): 210-212.

组别	例数	年龄（岁， ± s）	性别[例(%)]		转移率[例(%)]	TNM分级[例(%)]
组别	例数	年龄（岁， ± s）	男	女	转移率[例(%)]	1	2	3	4
观察组	12	66.1±12.5	2(16.7)	10(83.3)	3(25.0)	0(0.0)	0(0)	0(0)	12(100.0)
对照组	35	67.2±11.7	6(17.1)	29(82.9)	11(31.4)	13(37.1)	10(28.6)	8(22.9)	4(11.4)
统计值	?	1.640	1.320		0.021	?	7.158		?
P值	?	0.109	0.259		0.776	?	0.008^a		?

组别	例数	年龄（岁， ± s）	性别[例(%)]		转移率[例(%)]	TNM分级[例(%)]
组别	例数	年龄（岁， ± s）	男	女	转移率[例(%)]	1	2	3	4
观察组	12	66.1±12.5	2(16.7)	10(83.3)	3(25.0)	0(0.0)	0(0)	0(0)	12(100.0)
对照组	35	67.2±11.7	6(17.1)	29(82.9)	11(31.4)	13(37.1)	10(28.6)	8(22.9)	4(11.4)
统计值	?	1.640	1.320		0.021	?	7.158		?
P值	?	0.109	0.259		0.776	?	0.008^a		?

组别	例数	直径（cm, ± s)	纵横比［例(%)］		微钙化［例(%)］		血流情况［例(%)］		边界［例(%)］
组别	例数	直径（cm, ± s)	<1	≥1	是	否	少血流	多血流	清晰	模糊
观察组	12	5.36±1.17	10(83.3)	2(16.7)	1(8.3)	11(91.7)	2(16.7)	10(83.3)	0(0)	12(100.0)
对照组	35	1.73±1.36	19(54.3)	16(45.7)	12(34.3)	23(65.7)	13(37.1)	22(62.9)	28(80.0)	7(20.0)
统计值	?	5.267	4.869		4.591		4.265^a		6.537
P值	?	0.000^a	0.028^a		0.031^a		0.035		0.011^a
组别	回声均匀性［例(%)］		形态［例(%)］		囊性变［例(%)］		回声［例(%)］		被膜［例(%)］
组别	均匀	非均匀	规则	不规则	实性	囊实性	低回声	中等回声	受侵	未受侵
观察组	3(25.0)	9(75.0)	1(8.3)	11(91.7)	0(0.0)	12(100.0)	12(100.0)	0(0)	4(33.3)	8(66.7)
对照组	16(45.7)	19(54.3)	5(14.3)	30(85.7)	2(5.7)	33(94.3)	31(88.6)	4(11.4)	10(28.6)	25(71.4)
χ²值	4.106		2.680		2.139		2.872		2.964
P值	0.039^a		0.134		0.156		0.097		0.082

组别	例数	直径（cm, ± s)	纵横比［例(%)］		微钙化［例(%)］		血流情况［例(%)］		边界［例(%)］
组别	例数	直径（cm, ± s)	<1	≥1	是	否	少血流	多血流	清晰	模糊
观察组	12	5.36±1.17	10(83.3)	2(16.7)	1(8.3)	11(91.7)	2(16.7)	10(83.3)	0(0)	12(100.0)
对照组	35	1.73±1.36	19(54.3)	16(45.7)	12(34.3)	23(65.7)	13(37.1)	22(62.9)	28(80.0)	7(20.0)
统计值	?	5.267	4.869		4.591		4.265^a		6.537
P值	?	0.000^a	0.028^a		0.031^a		0.035		0.011^a
组别	回声均匀性［例(%)］		形态［例(%)］		囊性变［例(%)］		回声［例(%)］		被膜［例(%)］
组别	均匀	非均匀	规则	不规则	实性	囊实性	低回声	中等回声	受侵	未受侵
观察组	3(25.0)	9(75.0)	1(8.3)	11(91.7)	0(0.0)	12(100.0)	12(100.0)	0(0)	4(33.3)	8(66.7)
对照组	16(45.7)	19(54.3)	5(14.3)	30(85.7)	2(5.7)	33(94.3)	31(88.6)	4(11.4)	10(28.6)	25(71.4)
χ²值	4.106		2.680		2.139		2.872		2.964
P值	0.039^a		0.134		0.156		0.097		0.082

[1]	Zhong Yang, Jingye Shi, Xuedong Deng, Wei Jiang, Linliang Yin, Qi Pan, Hong Liang, Jianfang Ma, Zhenqi Wang, Jun Zhang, Shanshan Dong. Diagnostic value of prenatal ultrasound in fetal 22q11.2 microdeletion syndrome [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(09): 852-858.
[2]	Yanjuan Bao, Xiaohong Yang, Tao Zhang, Sheng Zhao, Li Zhang. Ultrasound diagnosis and clinical analysis of obstructed hemivagina and ipsilateral renal anomaly syndrome [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(09): 859-864.
[3]	Sirui Liu, Chenyang Zhao, Rui Zhang, Yixiu Zhang, Meng Yang. Comprehensive evaluation of hemodynamic parameters at different segments of the uterine artery in pregnant rats using Doppler ultrasonography [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(09): 877-883.
[4]	Jiali Sun, Lin Jin, Cuiqin Shen, Qingqing Chen, Yanping Lin, Zhaojun Li, Dong Xu. Ultrasound-guided robot-assisted percutaneous puncture： an experimental study [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(09): 884-889.
[5]	Xuebing Shi, Yingdong Xie, Ni Xie, Chaoli Xu, Bin Yang, Guo Sun. Acoustic radiation force imaging for evaluating efficacy of radiotherapy in unresectable hepatocellular carcinoma patients with portal vein tumor thrombus [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(08): 778-784.
[6]	Yang Li, Jinyu Cai, Xiaozhi Dang, Wanying Chang, Yan Ju, Yi Gao, Hongping Song. Application value of a deep learning-based model for generating strain elastography images using breast grayscale ultrasound images [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(06): 563-570.
[7]	Wei Hong, Xirong Ye, Zhihong Liu, Yinfeng Yang, Zhihong Lyu. Value of ultrasound radiomics combined with clinicopathological features in predicting complete pathological response to neoadjuvant chemotherapy for breast cancer [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(06): 571-579.
[8]	Ziyang Wang, Wenli Yang, Dongjun Li, Wei Chen, Qi Zhao, Yifeng Li, Rui Cui, Lin Shen, Qian Liu, Chuanchuan Wei. Clinical observation of the eyeball wall with high frequency linear array probe [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(06): 580-584.
[9]	Wenjing Xiang, Yan Xu, Tong Ru, Mingming Zheng, Yan Gu, Chenyan Dai, Xiangyu Zhu, Chenchen Yan. Application of neurosonography in prenatal diagnosis of fetal corpus callosum malformations [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(05): 470-476.
[10]	Wen Gu, Shouxin Ling, Haili Tang, Xuemei Gan. Comparison of two different surgical approaches for open radical surgery in patients with papillary thyroid cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 687-690.
[11]	Yu Wang, Fangquan Xu, Xuan Zhou, Xiaofeng Yao, Qiang Li. Improve the standardization of radical resection of differentiated thyroid cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 473-476.
[12]	Hui Sun, Changlin Li. Key considerations and strategies for radical resection of differentiated thyroid carcinoma [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 477-481.
[13]	Yifei Gao, Genxiang Liu, Changhua Sun, Guangjun Zhou. Application of recurrent laryngeal nerve monitoring in unilateral thyroidectomy and central lymph node dissection without inflatable axillary approach [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 483-486.
[14]	Yunlong Li, Xuliang Xia, Zhiqiang Jiang, Wei Liu, Kai Liu, Li Tang, Haozhong Liu, Siyuan Zhang. Clinical efficacy of three methods in the treatment of differentiated thyroid carcinoma [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 487-489.
[15]	Jing Han, Shaolong Hao, Hua Kang. Retrospective analysis of clinical features of single-center thyroid carcinoma patients in Beijing [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 490-493.

Please choose a citation manager

Content to export