Clinical significance of antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: a meta-analysis

doi:10.3877/cma.j.issn.1674-0793.2016.03.018

Abstract

Abstract:

Objective

To assess the infectious complications of antibiotic prophylaxis following transcatheter arterial chemoembolization (TACE) for patients with primary hepatocellular carcinoma (HCC).

Methods

All studies that have been published comparing the effects of prophylactic antibiotic treatment (study group) and no prophylactic antibiotic treatment (control group) on infectious complications in pa-tients with HCC following TACE were searched and evaluated strictly in rash quality, then the adopted stud-ies were analyzed by Meta-analysis. The risk ratio (RR) for infectious complications between the two groups were calculated.

Results

Totally four studies including 1 358 cases were analyzed. The cumulative cases in prophylactic antibiotic treatment group were 960, 83 of whom were reported postoperative infection, while in the control group, the number was 398 and 43 respectively. The pooled RR was 0.88, with a 95% confidence interval (0.62-1.24).

Conclusion

It is not routinely necessary for HCC patients to undergo an-tibotic prophylaxis following TACE.

Key words: Carcinoma, hepatocellular, Chemoembolization, therapeutic, Antibotic prophylaxis, Anti-bacterial agents, Meta-analysis

Yijie Li, Guowei Li, Xinfeng Huang, Qingan Zeng. Clinical significance of antibiotic prophylaxis in transarterial therapy of hepatocellular carcinoma: a meta-analysis[J]. Chinese Archives of General Surgery(Electronic Edition), 2016, 10(03): 231-234.

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Figures/Tables 4

References 13

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作者，发表时间	研究类型	性别（男/女，例）	年龄（岁）	患者/治疗（例）	肝癌治疗	抗生素应用方案
王江云，2005^［8］	RCT	-	55	60/60	TACE	先锋霉素Ⅴ术前30 min
高峰，2013^［9］	RCT	83/18	53	94/101	TACE	头孢呋辛术后连用3 d
朱文艳，2014^［11］	Non-RCT	284/70	56.39 ± 17.94	354/659	TACE	头孢菌素或氟喹诺酮类^a
邱晓玲，2014^［10］	Non-RCT	501/37	52.87 ± 12.33	538/538	TACE	未提及

作者，发表时间	研究类型	性别（男/女，例）	年龄（岁）	患者/治疗（例）	肝癌治疗	抗生素应用方案
王江云，2005^［8］	RCT	-	55	60/60	TACE	先锋霉素Ⅴ术前30 min
高峰，2013^［9］	RCT	83/18	53	94/101	TACE	头孢呋辛术后连用3 d
朱文艳，2014^［11］	Non-RCT	284/70	56.39 ± 17.94	354/659	TACE	头孢菌素或氟喹诺酮类^a
邱晓玲，2014^［10］	Non-RCT	501/37	52.87 ± 12.33	538/538	TACE	未提及

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