Preliminary efficacy report on primary great saphenous varicose veins of the combination therapy of high ligation and foam sclerotherapy

doi:10.3877/cma.j.issn.1674-0793.2017.06.015

Abstract

Abstract:

Objective

To discuss the clinical effect on primary great saphenous varicose veins of the combination therapy of high ligation and foam sclerotherapy.

Methods

Sixty cases were collected from January to December 2016 in Sun Yat-sen Memorial Hospital of Sun Yat-sen University, and were divided into two groups according to the treatment of great saphenous vein trunk: Group foam sclerotherapy, 26 cases with 30 limbs; Group vein stripped, 34 cases with 37 limbs. Operation time and methods, the volume of foam sclerosing agent consumed were recorded, as well as the recanalization rate of varicose veins in standing position, and the local reactions (including local skin necrosis and ulcer).

Results

3% foam sclerosing agent was applicated on the great saphenous vein trunk. the operation time and length of hospital stay in group foam sclerotherapy was significantly shorter, with statistical difference [(50.4±2.12) min vs (59.73±1.47) min, (1.96±0.11) d vs (4.53±1.07) d, t=22.862, 12.221, P<0.001]. The volume of 1% foam sclerosing agent consumed in the leg was reduced, which showed statistical difference [(3.53±0.31) ml vs (5.84±0.31) ml, t=28.425, P<0.01]. However, the recanalization rate and the incidence of phlebitis and pigmentation showed no statistically significant difference between the two groups.

Conclusion

The clinical effect of the combination therapy of high ligation and foam sclerotherapy on primary great saphenous varicose veins is minimally invasive, stable and reliable, safe, simple and cosmetic, which is worthy of rapid rehabilitation medicine concept and promotion.

Key words: Saphenous veins, Varicose veins, Ligation, Foam sclerotherapy

Kai Huang, Qinchang Chen, Xixia Lin, Zhibo Chen, Yonghui Li, Wenjie Wu, Qilin Liang, Lifen Fu, Honghao Li. Preliminary efficacy report on primary great saphenous varicose veins of the combination therapy of high ligation and foam sclerotherapy[J]. Chinese Archives of General Surgery(Electronic Edition), 2017, 11(06): 422-425.

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References 17

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组别	例数	性别（例,男/女）	年龄（岁，±s）	BMI（kg/m²,±s）	病史（年，±s）	近期抗凝药[例(%)]
硬化剂组	26	7/19	54.27±2.15	25.15±0.79	9.85±0.84	2(7.69)
剥脱组	34	8/26	52.26±2.12	24.57±0.88	11.03±0.71	6(17.65)
统计值		χ²=0.090	t=1.727	t=0.545	t=0.534	χ²=1.263
P值		0.764	0.541	0.395	0.205	0.261

组别	例数	性别（例,男/女）	年龄（岁，±s）	BMI（kg/m²,±s）	病史（年，±s）	近期抗凝药[例(%)]
硬化剂组	26	7/19	54.27±2.15	25.15±0.79	9.85±0.84	2(7.69)
剥脱组	34	8/26	52.26±2.12	24.57±0.88	11.03±0.71	6(17.65)
统计值		χ²=0.090	t=1.727	t=0.545	t=0.534	χ²=1.263
P值		0.764	0.541	0.395	0.205	0.261

组别	例数	患肢条数	患肢比例（例，左：右：双）	曲张面积^a（cm²，±s）	沉重感[例(%)]	乏力感[例(%)]
硬化剂组	26	30	14:8:4	3.07±0.16	10(33.33)	11（36.67）
剥脱组	34	37	23:8:3	3.22±0.20	16 (43.24)	13（35.14）
统计值			χ²=0.537	t=0.424	χ²=0.685	χ²=0.017
P值			0.673	0.883	0.408	0.897

组别	例数	患肢条数	患肢比例（例，左：右：双）	曲张面积^a（cm²，±s）	沉重感[例(%)]	乏力感[例(%)]
硬化剂组	26	30	14:8:4	3.07±0.16	10(33.33)	11（36.67）
剥脱组	34	37	23:8:3	3.22±0.20	16 (43.24)	13（35.14）
统计值			χ²=0.537	t=0.424	χ²=0.685	χ²=0.017
P值			0.673	0.883	0.408	0.897

组别	例数	手术时间（min, ±s）	住院时间（d, ±s）	主干血栓[例(%)]	小腿曲张静脉[例(%)]	3个月内复通率[例(%)]	1%泡沫硬化剂总量（ml, ±s）	浅静脉炎[例(%)]	色素沉着[例(%)]	VCSS分数（±s）	医院费用（元，±s）
硬化剂组	26	50.4±2.12	1.96±0.11	3(10.00)	2(6.67)	4(13.33)	3.53±0.31	5(16.67)	6(20.00)	1.0±0.4	12 534±255
剥脱组	34	59.73±1.47	4.53±1.07	7(18.92)	7(18.92)	4(10.81)	5.84±0.31	6(16.22)	5(13.51)	2.1±0.3	16 879±368
统计值		t=22.862	t=12.221	χ²=0.213	χ²=2.139	χ²=0.100	t=28.425	χ²=0.508	χ²=0.508	t=1.460	t=0.277
P值		0.001	0.001	0.128	0.144	0.752	0.001	0.476	0.476	0.149	0.783

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