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Chinese Archives of General Surgery(Electronic Edition) ›› 2020, Vol. 14 ›› Issue (02): 150-153. doi: 10.3877/cma.j.issn.1674-0793.2020.02.018

Special Issue:

• Review • Previous Articles     Next Articles

Advances and prospects of HER-2-specific CAR-T cell in the treatment of gastric cancer

Caixia Yang1, Yi Shang1,()   

  1. 1. No.1 Ward of the Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou 730000, China
  • Received:2019-03-25 Online:2020-04-01 Published:2020-04-01
  • Contact: Yi Shang
  • About author:
    Corresponding author: Shang Yi, Email:

Abstract:

Traditional therapy has limited efficacy on gastric cancer, and with the rapid development of molecular biology and genetic engineering technology, human epidermal growth factor receptor 2 (HER-2)-specific chimeric antigen receptor T cell (CAR-T), a new model of adoptive immune cell therapy, has shown tremendous potential and promising prospect. It has a significant effect on hematological malignancies and has made remarkable progress in solid tumor research. However, due to the highly heterogeneous and complex tumor microenvironment, the treatment of HER-2-specific CAR-T cell for gastric cancer is still challenging. In this review, we summarized the development, research progress, challenges and strategies of HER-2-specific CAR-T cells in the treatment of solid gastric cancer, so as to find a safe and effective treatment for solid tumors in the future.

Key words: Stomach noplasms, Receptors, antigen, T-cell, Receptor, epidermal growth factor, Immunotherapy, adoptive

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