Meta-analysis of the tracer effect of lymph node in radical gastrectomy with carbon Nano-Particle

doi:10.3877/cma.j.issn.1674-0793.2021.01.019

Abstract

Abstract:

Objective

To evaluate the effect of carbon Nano-Particle on lymph node tracing in radical gastrectomy by Meta-analysis.

Methods

A study search was undertaken in PubMed, Cochrane Library, FMRS, CNKI, Wanfang and VIP database from the date of their establishment to May 2020. RevMan 5.3 software was used to analyze the effect of node tracing.

Results

A total of 1 402 patients with 19 RCTs were enrolled, including 701 cases in the Nano-Particle group and 701 in the control group. Numbers of harvested lymph nodes, rate of micro lymph nodes, rate of lymph node metastasis in the Nano-Particle group were better than those in the control group, and the metastasis rate of black-dyed lymph nodes was significantly higher than that of non black-dyed lymph nodes in the Nano-Particle group, with statistically significant differences (Z=8.27, 3.54, 2.59, 4.06; all P<0.05). Funnel plot showed no significant publication bias in the number of harvested lymph nodes between the two groups (P=0.07).

Conclusion

The application of Nano-Particle in radical gastrectomy of gastric cancer is helpful to clean lymph nodes and micro lymph nodes accurately, and improve the detection of metastatic lymph nodes, which is helpful to the judgment of postoperative pathological stage and prognosis evaluation.

Key words: Gastric neoplasms, Lymph node, Nano-Particle, Meta analysis

Haibo Xiong, Song Yu, Xuelai He, Nengyi Hou, Yue Wang, Junwen Fu, Hua Zhang, Jie Xu, Kang Wang, Minghui Pang. Meta-analysis of the tracer effect of lymph node in radical gastrectomy with carbon Nano-Particle[J]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(01): 75-80.

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References 39

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