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Chinese Archives of General Surgery(Electronic Edition) ›› 2023, Vol. 17 ›› Issue (03): 211-216. doi: 10.3877/cma.j.issn.1674-0793.2023.03.010

• Original Article • Previous Articles     Next Articles

Prognostic expression of disheveled-associated activator of morphogenesis 1 and Fascin in breast cancer and their relationship with clinicopathological parameters and prognosis

Ruwen Xing(), Shuangjin Li, Yongqiang Hou, Yan Wei, Wenjuan Tian   

  1. Department of General Surgery, Shijiazhuang Sixth Hospital, Shijiazhuang 050011, China
    Department of Orthopaedic Surgery, Shijiazhuang Yanzhao Hospital, Shijiazhuang 050035, China
    Department of Orthopaedics, Baoding City Yixian Xinglin Hospital, Baoding 074200, China
    Department of Surgery, Zhengding County People’s Hospital, Shijiazhuang 050800, China
  • Received:2022-10-28 Online:2023-06-01 Published:2023-06-15
  • Contact: Ruwen Xing

Abstract:

Objective

To explore the correlation between disheveled-associated activator of morphogenesis 1 (Daam1) and Fascin expression in breast cancer tissues and their relationship with clinicopathological parameters and prognosis.

Methods

A total of 92 breast cancer patients admitted to Shijiazhuang Sixth Hospital from January 2019 to December 2021 were selected as the research objects. The expression of Daam1 and Fascin proteins and mRNA in breast cancer tissues and corresponding adjacent tissues was detected by immunohistochemistry and quantitative real-time PCR, respectively. The relationship between Daam1 and Fascin protein expression and clinicopathological parameters of breast cancer was analyzed. Kaplan-Meier method was used to analyze the relationship between Daam1 and Fascin expression and breast cancer prognosis. The correlation between Daam1 and Fascin expression was analyzed using Spearman rank correlation or Pearson correlation.

Results

The positive rates of Daam1 and Fascin protein and mRNA expression levels in breast cancer tissues were significantly higher than those in adjacent normal tissues, and the differences were statistically significant (P<0.01). Positive expression of Daam1 was significantly associated with distant metastasis in breast cancer (P<0.05). Fascin-positive expression was significantly associated with hypodifferentiation, PR positivity, ER positivity, lymph node metastasis and distant metastasis in breast cancer tissues (P<0.05). The cumulative disease-free survival rates in the Daam1 and Fascin-positive expression groups were significantly lower than those in the Daam1 and Fascin-negative expression groups, and the differences were statistically significant (Log-rank χ2=3.883, 5.159; P=0.049, 0.023). The expression of Daam1 and Fascin protein and mRNA in breast cancer tissues were significantly positively correlated (r=0.742, 0.689, both P<0.05).

Conclusion

Daam1 and Fascin are positively correlated and highly expressed in breast cancer tissues, closely related to the clinicopathological features and prognosis of patients, and may be involved in the occurrence, development and metastasis of breast cancer.

Key words: Breast neoplasms, Daam1, Fascin, Clinicopathological parameters, Prognosis

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