To explore the feasibility and safety of pancreaticoduodenectomy (PD) combined with liver resection.

A retrospective analysis was conducted on the clinical data of 5 patients who underwent PD combined with liver resection at Peking University Shougang Hospital from April 2018 to April 2023. There was 1 female and 4 males, with an average age of (54±7.35) years old. One case was diagnosed distal cholangiocarcinoma invading the hilar bile duct; 1 case of pancreatic cancer with solitary metastasis of liver; 1 case of duodenal stromal tumor with liver metastasis; 1 case of rectal and pancreatic neuroendocrine tumor (G2) with type Ⅱ liver metastasis; 1 case of right colon cancer (T4bN1aM0) with partial resection of the right colon and duodenum, local recurrence of duodenal anastomosis after duodenostomy, bleeding, and liver metastasis. The general information, intraoperative condition, postoperative complications, mortality rate within 90 days, and prognosis were analyzed and summarized.

One case underwent PD combined with large-scale liver resection (unplanned liver resection), and the other 4 cases of PD combined with small-scale liver resection (all planned liver resection). In addition, there were 3 cases of combined vascular resection and reconstruction. The surgical time was (559±60.97) minutes, and intraoperative bleeding was (560±219.08) ml. All cases underwent R0 resection. Postoperative Clavien-Dindo complications: grade Ⅲb in 1 case, grade Ⅱ in 4 cases. There were no deaths within 90 days after surgery. All the 5 cases were followed up, while 4 cases survived, with a follow-up period of 12 to 68 months, and 1 case died 12 months after surgery.

Under the premise of carefully grasping the surgical indications, precisely preoperative evaluation and preparation, as well as standardized intraoperative procedures, pancreaticoduodenectomy combined with liver resection is a feasible and safe treatment method.