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Chinese Archives of General Surgery(Electronic Edition) ›› 2024, Vol. 18 ›› Issue (06): 452-456. doi: 10.3877/cma.j.issn.1674-0793.2024.06.012

• Review • Previous Articles     Next Articles

Research progress of phosphoenolpyruvate carboxykinase-1 in malignant tumors

Huayue Yan1, Zixiang Liu1, Shaobo Zhou1,()   

  1. 1.Department of General Surgery, Bengbu Hospital of Shanghai General Hospital (the Second Affiliated Hospital of Bengbu Medical University), Bengbu 233000, China
  • Received:2024-02-06 Online:2024-12-01 Published:2024-12-13
  • Contact: Shaobo Zhou

Abstract:

Phosphoenolpyruvate carboxykinase-1 ( PCK1 ) is one of the key enzymes in the gluconeogenesis pathway in vivo. In recent years, studies have confirmed that PCK1 plays a key regulatory role in the occurrence and development of various tumors such as gastrointestinal tumors, renal clear cell carcinoma, breast cancer, and melanoma. Based on the overview of PCK1, this article focuses on the unique role of PCK1 in tumor differential expression, signal transduction, physiological processes, and regulation of tumor drug sensitivity, aiming to provide new ideas for clinical development of anticancer drugs.

Key words: Phosphoenolpyruvate carboxykinase-1, Malignant tumors, Signal transduction, Physiological process, Drug treatment, Mechanisms

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