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中华普通外科学文献(电子版) ›› 2019, Vol. 13 ›› Issue (02) : 157 -160. doi: 10.3877/cma.j.issn.1674-0793.2019.02.016

所属专题: 文献

综述

α-倒捻子素抗肿瘤作用机制研究进展
赵斌1, 王翔1, 王小龙2, 汤嵩1, 毛杰1,()   
  1. 1. 730030 兰州大学第二医院普外科
    2. 742100 陇南,甘肃西和县十里镇医院普外科
  • 收稿日期:2018-05-25 出版日期:2019-04-01
  • 通信作者: 毛杰
  • 基金资助:
    兰州市人才创新创业项目(2017-RC-64)

Research progress on the antitumour mechanism of α-Mangostin

Bin Zhao1, Xiang Wang1, Xiaolong Wang2, Song Tang1, Jie Mao1,()   

  1. 1. Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, China
    2. Department of General Surgery, Shili Hospital of Xihe County, Longnan 742100, China
  • Received:2018-05-25 Published:2019-04-01
  • Corresponding author: Jie Mao
  • About author:
    Corresponding author: Mao Jie, Email:
引用本文:

赵斌, 王翔, 王小龙, 汤嵩, 毛杰. α-倒捻子素抗肿瘤作用机制研究进展[J]. 中华普通外科学文献(电子版), 2019, 13(02): 157-160.

Bin Zhao, Xiang Wang, Xiaolong Wang, Song Tang, Jie Mao. Research progress on the antitumour mechanism of α-Mangostin[J]. Chinese Archives of General Surgery(Electronic Edition), 2019, 13(02): 157-160.

α-倒捻子素是山竹子果壳中分离出的最丰富和最具生物活性的一种氧杂蒽酮类化合物。多项研究发现α-倒捻子素具有独特抗肿瘤效应,如可诱导肿瘤细胞周期阻滞、抑制细胞存活、诱导细胞凋亡和分化、减少炎症和黏附、降低癌细胞浸润和转移的能力。本文综述了近年来α-倒捻子素在抗肿瘤方面的研究发现与进展,为新药的进一步研发及应用提供有价值的研究方向。

α-Mangostin is the most bioactive anoxanthone compound isolated from the shell of mangosteen. Many studies have found that α-Mangostin has antitumor effect, such as that it can induce cell cycle arrest, inhibit cell survival, induce apoptosis and differentiation, reduce inflammation and adhesion, and reduce the invasion and metastasis of cancer cells. This article reviews the recent studies on the antitumor effect of α-Mangostin to provide valuable directions for the development and application of anti-tumor drug.

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