Role of microRNAs in the occurrence and development of gastrointestinal tumor

doi:10.3877/cma.j.issn.1647-0793.2013.02.014

Abstract

Abstract:

MicroRNAs (miRNAs) are a kind of small endogenous non-coding RNA which play an important role in all the organisms. Growing evidences indicated that miRNAs may act as oncogenes or tumor suppressors to involve in the development and progression of tumor. Further study on the identification and mechanisms of miRNAs will bring a great breakthrough in the pathogenesis, diagnosis and treatment of gastrointestinal tumors. There will be good prospects in the clinical application.

Key words: MiRNAs, Gastrointestinal tumor, Gene Regulation

Wei WANG, Hua-ying DONG, Jia YAO, Yu ZHANG, Xiao-jie ZHONG, Peng TANG, Kai SUN, Cheng-tang WU. Role of microRNAs in the occurrence and development of gastrointestinal tumor[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(02): 133-136.

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References 35

1	Lee RC. Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75(5): 843-854.
2	朱嘉琦，王国坤，秦永文, 等. 循环血中microRNAs作为疾病标志物的研究进展. 生命科学, 2010，22(7): 655-660.
3	Lima RT, Busacca S, Almeida GM, et al. MicroRNA regulation of core apoptosis pathways in cancer. Eur J Cancer, 2011, 47(2): 163-174.
4	冯琼，雷章，卢宏达. microRNA与肿瘤关系的研究[J/CD]. 中华临床医师杂志:电子版, 2012, 6(15): 4390-4393.
5	Calin GA, Dum itru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA gene miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA, 2002, 99(24): 15524-15529.
6	Pan YZ, Gao W, Yu AM. MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab Dispos, 2009, 37(10): 2112-2117.
7	Cimmino A, Calin GA, Fabbri M, et al. MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA, 2005, 102(39): 13944-13949.
8	Voorhoeve PM, le Sage C, Schrier M, et al. A genetic screen implicates m iRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell, 2006, 124(6): 1169-1181.
9	Iorio MV, FerracinM, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res, 2005, 65(16): 7065-7070.
10	Jeong JY, Kim MG, Ha TK, et al. Prognostic factors on overall survival in lymph node negative gastric cancer patients who underwent curative resection. J Gastric Cancer, 2012, 12(4): 210-216.
11	Sun K, Wang W, Zeng JJ, et al. MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma. Acta Pharmacol Sin, 2011, 32(3): 375-384.
12	赫捷，赵平，陈万青. 2011中国肿瘤登记年报. 北京: 军事医学科学出版社. 2011.
13	曾红梅，郑荣寿，张思维, 等. 1989-2008年中国恶性肿瘤死亡趋势分析. 中华肿瘤杂志, 2012, 34(7): 525-531.
14	Johnson CD, Esquela-Kerscher A, Stefani G, et al. The let-7 microRNA represses cel proliferation pathways in human cells. Cancer Res, 2007, 67(16): 7713-7722.
15	Lao K, Xu NL, Sun YA, et al. Real time PCR profiling of 330 human microRNAs. Biotechnol J, 2007, 2(1): 33-35.
16	Xiao B, Guo J, Miao Y, et al. Detection of miR-106a in gastric carcinoma and its clinical significance. Clin Chin Acta, 2009, 400(1-2): 97-102.
17	Tong AW, Nemunaitis J. Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy? Cancer Gene Ther, 2008, 15(6): 341-355.
18	Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA, 2006, 103(7): 2257-2261.
19	Michael MZ, O' Connor SM, van Holst Pellekaan NG, et al. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol Cancer Res, 2003, 1(12): 882-891.
20	Shi B, Sepp-Lorenzino L, Prisco M, et al. MicroRNA145 targets the insulin receotor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem, 2007, 282(45): 32582-32590.
21	Lanza G, Ferracin M, Gafa R, et al. mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Mol Cancer, 2007, 6: 54.
22	Bandres E, Cubedo E, Agirre X, et al. Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer, 2006, 5: 29.
23	Akao Y, Nakagawa Y, Naoe T. let-7 microRNA functions as a potenital growth suppressor in human colon cancer cells. Biol Pharm Bull, 2006, 29(5): 903-906.
24	Asngani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppress or pdcd4 an stimulates invasion, intravasation and metastasis in colorectal cancer. Onocogene, 2008, 27(15): 2128-2136.
25	Sayed D, Rane S, Lypowy J, et al. MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol Biol Cell, 2008, 19(8): 3272-3282.
26	Burk U, Schubert J, Wellner U, et al. A reciprocal repression between ZEBI and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep, 2008, 9(6): 582-589.
27	Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004, 116(2): 281-297.
28	RouhiA, Mager DL, Humphries RK, et al. MiRNAs, epigenetics, and cancer. Mamm Genome, 2008, 19(7-8): 517-525.
29	Wei B, Pei G. microRNAs: critical regulators in Th17 cells and players in diseases. Cell Mol Immunol, 2010, 7(3): 175-181.
30	Lee I, Ajay SS, Yook JI, et al. New class of microRNA targets containing simultaneous 5'-UTR and3'-UTR interaction site. Genome Res, 2009, 19(7): 1175-1183.
31	O’rom UA, Nielsen FC, Lund AH. MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell, 2008, 30(4): 460-471.
32	Ruvkun G. Molecular biology. Glimpses of a tiny RNA world. Science, 2001, 294(5543): 797-799.
33	Naguibneva I, Ameyar-Zazoua M, Polesskaya A, et al. The microRNA miR-181 targets the homeobox Protein HOX-A11 during mammalian myoblast different ation. Nat Cell Biol, 2006, 8(3): 278-284.
34	Cichocki F, Felices M, McCullar V, et al. Cutting edge: microRNA-181 promotes human NK cell development by regulating Notch signaling. J Immunol, 2011, 187(1 2): 6171-6175.
35	Li YG, Zhang PP, Jiao KL, et al. Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction. Microvasc Res, 2009, 78(3): 393-404.

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