Effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer

doi:10.3877/cma.j.issn.1647-0793.2013.03.008

Abstract

Abstract:

Objective

To study the effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer.

Methods

From June 2011 to June 2012, 52 patients underwent radical gastrectomy for gastric cancer were randomized to two groups in double-blind manner: trial group(28 cases) and control group(24 cases). Patients in the trial groups were subjected to intravenous infusion of 100 000 U of Ulinastatin (UTI) twice a day on the postoperative day 0-3, and those in the control group were injected the same volume of saline. The level of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), white blood cell (WBC) counts in blood samples were measured before surgery and the 1st, 2nd, 3rd, 6th day after surgery. The systemic inflammatory response syndrome (SIRS) score was also commented.

Results

Postoperative IL-6, TNF-α, WBC counts and SIRS score were significantly higher on the 1st, 2nd and 3rd day after surgery compared with the day before surgery (P < 0.05). There was no significant difference after srygery between the trial group and the control group in WBC counts and SIRS score. While the serum IL-6 and TNF-α level was significantly lower on the 1st, 2nd and 3rd day after surgery in experimental group compared with the control group (P < 0.05).

Conclusions

Inflammatory response occurs after suygery in Gastric cancer patients. Ulinastatin could inhibit the postoperative serum IL-6, TNF-α concentration.

Key words: Ulinastatin, Gastric cancer, Interleukin-6, Tumor necrosis factor-α

Chun-zai FENG, Yong-hui SU, Bing-zong HOU, Ji-yan LI, Yao WANG, Hong CHEN. Effect of Ulinastatin on postoperative inflammatory responses in patients with gastric cancer[J]. Chinese Archives of General Surgery(Electronic Edition), 2013, 07(03): 197-200.

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Figures/Tables 4

References 8

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组别	例数	术前1 d	术后1 d	术后2 d	术后3 d	术后6 d
试验组	28	10.3±7.2	122.7±71.6^a	103.1±50.8^a	62.6±37.9^a	15.8±10.6^a
对照组	24	11.6±8.5	196.4±92.3^a	155.8±81.4^a	93.3±51.2^a	19.1±14.9^a
t值	?	0.60	3.24	2.84	2.48	0.93
P值	?	0.55	<0.01	<0.01	0.02	0.36

组别	例数	术前1 d	术后1 d	术后2 d	术后3 d	术后6 d
试验组	28	10.3±7.2	122.7±71.6^a	103.1±50.8^a	62.6±37.9^a	15.8±10.6^a
对照组	24	11.6±8.5	196.4±92.3^a	155.8±81.4^a	93.3±51.2^a	19.1±14.9^a
t值	?	0.60	3.24	2.84	2.48	0.93
P值	?	0.55	<0.01	<0.01	0.02	0.36

组别	例数	术前1 d	术后1 d	术后2 d	术后3 d	术后6 d
试验组	28	22.3±13.1	213.7±101.2^a	163.1±80.8^a	82.6±38.9^a	31.8±16.7^a
对照组	24	20.6±11.5	276.4±112.3^a	215.8±91.8^a	123.3±61.2^a	32.1±17.9^a
t值	?	0.49	2.12	2.20	2.90	0.06
P值	?	0.62	0.04	0.03	<0.01	0.95

组别	例数	术前1 d	术后1 d	术后2 d	术后3 d	术后6 d
试验组	28	22.3±13.1	213.7±101.2^a	163.1±80.8^a	82.6±38.9^a	31.8±16.7^a
对照组	24	20.6±11.5	276.4±112.3^a	215.8±91.8^a	123.3±61.2^a	32.1±17.9^a
t值	?	0.49	2.12	2.20	2.90	0.06
P值	?	0.62	0.04	0.03	<0.01	0.95

组别	例数	术前1 d	术后1 d	术后2 d	术后3 d	术后6 d
试验组	28	5.6±2.1	13.7±4.7^a	12.1±4.8^a	10.6±3.9^a	6.8±3.7
对照组	24	5.1±2.5	14.4±5.3^a	14.8±5.6^a	12.3±4.2^a	7.1±4.9
t值	?	0.78	0.50	1.87	1.51	0.25
P值	?	0.44	0.62	0.07	0.14	0.80

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