Abstract:
Objective
To summarize the results of simultaneous pancreas-kidney transplantation(SPK)in the treatment of DM with uremia.
Methods
Seven cases of DM with uremia were received SPK from January 2005 to September 2008.The pancreatic allograft exocrine secretion was drained into the proximal jejunum via a side-to-side duodenojujunostomy. Quadruple immunosuppressive regimes including tacrolimus/cyclosporine,mycophenolate mofetil(MMF),methylprednisolone and anti-CD25 monoclonal antibody were used.
Results
SPK was successfully applied to all patients without serious complications such as pancreatitis, graft and pancreatic fistula. Seven of the patients had achieved immediate kidney allograft function and six of them achieved euglycemia with insulin independent ten days after the operation. Acute rejection were observed in four cases，one case died of cardio-cerebral vascular accident and another three cases were reversed effectively by the treatment of ATG+MP.Early postoperative complications involved wound infection and bleeding.
Conclusion
SPK is efficacious treatmentto the patients of DMwith uremia.
Key words:
Pancreastransplantation,
Kidneytransplantation,
Diabetesmellitus
An HU, Dong-ping WANG, Xiao-shun HE, Lin-wei WU, An-bin HU, Wei-qiang JU, Qiang TAI, Guo-dong WANG, Yi MA, Xiao-feng ZHU. Simultaneous pancreas-kidney transplantation treating the DM with uremia (report of 7 cases)[J]. Chinese Archives of General Surgery(Electronic Edition), 2009, 03(03): 216-219.